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Article
Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas
Malignant gliomas, the deadliest of brain neoplasms, show rampant genetic instability and resistance to genotoxic therapies, implicating potentially aberrant DNA damage response (DDR) in glioma pathogenesis an...
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Article
Open AccessEffects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells
Neuroblastoma (NB), a sympathetically derived childhood tumour, shows characteristics of neuronal precursor cells, suggesting a halted differentiation process. We have previously shown that the Notch signallin...