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Article
The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis
Oncogenic stimuli trigger the DNA damage response (DDR) and induction of the alternative reading frame (ARF) tumor suppressor, both of which can activate the p53 pathway and provide intrinsic barriers to tumor...
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Article
Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1
53BP1 is a mediator of DNA damage response (DDR) and a tumor suppressor whose accumulation on damaged chromatin promotes DNA repair and enhances DDR signaling. Using foci formation of 53BP1 as a readout in two...
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Article
Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia
Maintaining genomic integrity is critical to avoid life-threatening disorders, such as premature aging, neurodegeneration and cancer. A multiprotein cascade operates at sites of DNA double-strand breaks (DSBs)...
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Article
Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas
Malignant gliomas, the deadliest of brain neoplasms, show rampant genetic instability and resistance to genotoxic therapies, implicating potentially aberrant DNA damage response (DDR) in glioma pathogenesis an...
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Article
Method of sampling and laboratory extraction affects interpretation of grain infestation by storage pests
European-Union countries undergo the process of unifying laws. This is also true for protocols designated for monitoring and evaluation of pests and pesticide risks. This study was aimed at exploring whether d...
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Article
The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer
The ataxia-telangiectasia-mutated (ATM) kinase is a key transducer of DNA damage signals within the genome maintenance machinery and a tumour suppressor whose germline mutations predispose to familial breast c...
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Article
DNA damage signalling guards against activated oncogenes and tumour progression
DNA damage response (DDR), the guardian of genomic integrity, emerges as an oncogene-inducible biological barrier against progression of cancer beyond its early stages. Recent evidence from both cell culture a...
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Article
DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours
MDC1 and 53BP1 are critical components of the DNA damage response (DDR) machinery that protects genome integrity and guards against cancer, yet the tissue expression patterns and involvement of these two DDR a...
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Article
The ontogeny of soldiers in Prorhinotermes simplex (Isoptera, Rhinotermitidae)
The ontogeny of the soldier caste in Prorhinotermes simplex is studied with emphasis on the instar origin of soldiers, the duration of the presoldier stage, and changes in external anatomy during the soldier morp...
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Article
Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites
Although several recurrent genetic aberrations are known to occur in MALT lymphoma, no comprehensive study on the most prevalent MALT lymphoma-associated genetic aberrations is available. We therefore screened...
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Article
Functionalized surfaces of polylactide modified by Langmuir–Blodgett films of amphiphilic block copolymers
To modify the surface of poly(L-lactide) (PLA) supports, we have investigated the feasibility to deposit on the PLA surface Langmuir–Blodgett films of amphiphilic block copolymers based on poly(L-lactide). AB ...
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Article
G1/S control and its deregulation in cancer
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Article
Arteriitis temporalis — Visusverlust trotz Soforttherapie Diagnostische und therapeutische Aspekte bei Morbus Horton
Ungeachtet einer unmittelbar nach Aufnahme in die Klinik durchgeführten hochdosierten Steroidtherapie erlitt eine 69jährige Patientin eine Amaurose des rechten, zunächst nur teilweise funktionsgestörten Auges.
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Article
Über den Einfluβ von Wachstumsfaktoren auf Morphologie und Zelldichte des Endothels von in Gewebekultur aufbewahrten humanen Spenderhornhäuten
Spenderhornhäute können bis zu 4 Wochen in Organkultur (bei 31 °C) aufbewahrt werden, wobei sich das Kulturmedium aus einer modifizierten MEM-Lösung zusammensetzt. Ein signifikanter Teil (ca. 20%) der Spenderh...
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Article
Comparative study of human monocyte and platelet adhesion to hydrogels in vitro – effect of polymer structure
Blood platelet and monocyte adhesion was studied in vitro with respect to the influence of hydrophilic polymer chemical functional groups and their charge. The results showed that the strongest adhesion of hum...
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Article
Potential role for concurrent abnormalities of the cyclin D1, p16CDKN2 and p15CDKN2B genes in certain B cell non-Hodgkin’s lymphomas. Functional studies in a cell line (Granta 519)
Abnormalities of several cell-cycle regulatory genes including cyclin D1, p16CDKN2 and p15CDKN2B have been described in B cell non-Hodgkin’s lymphoma (B-NHL). We describe a new B-NHL cell line (Granta 519), with ...
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Chapter
Elastical Properties of Aerogels -a Sensitive Monitor of Structural Changes
We present two examples of tiny changes in the microstructure of silica aerogels. Firstly, the elastic modulus of supposedly identical samples dried in autoclaves of different volumes were examined. A higher e...
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Article
Macrophage recognition of polymers: effect of carboxylate groups
The effect of anionic carboxylate groups in copolymers of 2-hydroxyethyl methacrylate with sodium methacrylate on the adsorption of albumin, adhesion, spreading and fusion of macrophages has been demonstrated....
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Chapter
Ways for the Removal of the Main Disadvantages of Force Transducers With Semiconductor Strain Gages
The up-to-date electronic components allow to design such devices that are capable of very precisely measuring and processing the electric signals even in the microvolt range. This facility makes very easy the...
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Chapter
Early Wavelets in the VECP
Utilizing a Maxwellian view optical system to present light flashes to the right eye, electroretinograms (ERG) and visual evoked cortical potentials (VECP) were recorded from normal subjects. The first 120 mS ...
