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Article

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

Defining mechanisms that generate intratumour heterogeneity and branched evolution may inspire novel therapeutic approaches to limit tumour diversity and adaptation. SETD2 (Su(var), Enhancer of zeste, Trithorax-d...

N Kanu, E Grönroos, P Martinez, R A Burrell, X Yi Goh, J Bartkova… in Oncogene (2015)