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  1. Article

    Open Access

    Markers associated with genomic instability, immunogenicity and immune therapy responsiveness in Metaplastic carcinoma of the breast: Expression of γH2AX, pRPA2, P53, PD-L1 and tumor infiltrating lymphocytes in 76 cases

    Metaplastic breast cancer (MpBC) is an aggressive subtype of breast carcinoma that is often resistant to conventional chemotherapy. Therefore, novel treatment strategies are urgently needed. Immune check point...

    S. Voutilainen, P. Heikkilä, J. Bartkova, H. Nevanlinna, C. Blomqvist… in BMC Cancer (2022)

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  2. No Access

    Article

    Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress

    Chromatin DNA damage response (DDR) is orchestrated by the E3 ubiquitin ligase ring finger protein 168 (RNF168), resulting in ubiquitin-dependent recruitment of DDR factors and tumor suppressors breast cancer ...

    K Chroma, M Mistrik, P Moudry, J Gursky, M Liptay, R Strauss, Z Skrott, R Vrtel… in Oncogene (2017)

  3. Article

    Open Access

    SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

    Defining mechanisms that generate intratumour heterogeneity and branched evolution may inspire novel therapeutic approaches to limit tumour diversity and adaptation. SETD2 (Su(var), Enhancer of zeste, Trithorax-d...

    N Kanu, E Grönroos, P Martinez, R A Burrell, X Yi Goh, J Bartkova… in Oncogene (2015)

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  4. Article

    Open Access

    Immortalised breast epithelia survive prolonged DNA replication stress and return to cycle from a senescent-like state

    Mammalian cells have mechanisms to counteract the effects of metabolic and exogenous stresses, many of that would be mutagenic if ignored. Damage arising during DNA replication is a major source of mutagenesis...

    A Maya-Mendoza, J M Merchut-Maya, J Bartkova, J Bartek, C H Streuli… in Cell Death & Disease (2014)

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  5. Article

    The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

    Oncogenic stimuli trigger the DNA damage response (DDR) and induction of the alternative reading frame (ARF) tumor suppressor, both of which can activate the p53 pathway and provide intrinsic barriers to tumor...

    K Evangelou, J Bartkova, A Kotsinas, I S Pateras, M Liontos… in Cell Death & Differentiation (2013)

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  6. No Access

    Article

    A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response

    One major challenge in cancer research is to understand the complex interplay between the DNA damage response (DDR), genomic integrity, and tumor development. To address these issues, we analyzed 43 bladder tu...

    T Schepeler, P Lamy, V Hvidberg, J R Laurberg, N Fristrup, T Reinert… in Oncogene (2013)

  7. No Access

    Article

    Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas

    Malignant gliomas, the deadliest of brain neoplasms, show rampant genetic instability and resistance to genotoxic therapies, implicating potentially aberrant DNA damage response (DDR) in glioma pathogenesis an...

    J Bartkova, P Hamerlik, M-T Stockhausen, J Ehrmann, A Hlobilkova, H Laursen… in Oncogene (2010)

  8. No Access

    Article

    The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer

    The ataxia-telangiectasia-mutated (ATM) kinase is a key transducer of DNA damage signals within the genome maintenance machinery and a tumour suppressor whose germline mutations predispose to familial breast c...

    J Tommiska, J Bartkova, M Heinonen, L Hautala, O Kilpivaara, H Eerola… in Oncogene (2008)

  9. No Access

    Article

    DNA damage signalling guards against activated oncogenes and tumour progression

    DNA damage response (DDR), the guardian of genomic integrity, emerges as an oncogene-inducible biological barrier against progression of cancer beyond its early stages. Recent evidence from both cell culture a...

    J Bartek, J Bartkova, J Lukas in Oncogene (2007)

  10. No Access

    Article

    DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours

    MDC1 and 53BP1 are critical components of the DNA damage response (DDR) machinery that protects genome integrity and guards against cancer, yet the tissue expression patterns and involvement of these two DDR a...

    J Bartkova, Z Hořejs̆í, M Sehested, J M Nesland, E Rajpert-De Meyts… in Oncogene (2007)

  11. Article

    G1/S control and its deregulation in cancer

    J Bartek, C Lukas, C Sørensen, E Santoni-Rugiu, J Bartkova… in Breast Cancer Research (2000)

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  12. No Access

    Article

    Potential role for concurrent abnormalities of the cyclin D1, p16CDKN2 and p15CDKN2B genes in certain B cell non-Hodgkin’s lymphomas. Functional studies in a cell line (Granta 519)

    Abnormalities of several cell-cycle regulatory genes including cyclin D1, p16CDKN2 and p15CDKN2B have been described in B cell non-Hodgkin’s lymphoma (B-NHL). We describe a new B-NHL cell line (Granta 519), with ...

    DM Jadayel, J Lukas, E Nacheva, J Bartkova, G Stranks, PJJC De Schouwer, D Lens… in Leukemia (1997)

  13. No Access

    Article

    The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer

    The relationship between c-erbB-2 gene expression (assessed immunohistochemically), S-phase fraction (SPF) and prognosis has been analysed in 172 women with primary breast cancer. c-erbB-2 staining was indepen...

    SM O'Reilly, DM Barnes, RS Camplejohn, J Bartkova, WM Gregory… in British Journal of Cancer (1991)

  14. No Access

    Article

    Keratin 19 expression in the adult and develo** human mammary gland

    In the adult human mammary gland, most of the luminal epithelial cells express keratin 19 (K19+). However, in some small ducts and terminal ductal lobular units where branching would be expected to occur durin...

    J. Bartek, J. Bartkova, J. Taylor-Papadimitriou in The Histochemical Journal (1990)

  15. No Access

    Article

    Secretory component in differentiating normal epithelium, benign lesions and malignancy in the human breast as monitored by monoclonal antibodies

    An immunohistochemical study of the expression of the secretory component (SC) in human mammary gland epithelium at various stages of differentiation, as well as in benign and malignant breast tumours, was und...

    J. Bártek, H. Tlaskalová-Hogenová, Z. Stašková, J. Šimečková, B. Vojtěšek… in Histochemistry (1989)

  16. No Access

    Article

    HLA-DR antigens on differentiating human mammary gland epithelium and breast tumours

    The staining pattern of a monoclonal antibody directed to the monomorphic determinant of HLA-DR antigens was examined on sections of human mammary gland tissues at various stages of differentiation as well as ...

    J Bártek, M Petřek, B Vojtěšek, J Bártková, J Kovařík… in British Journal of Cancer (1987)

  17. No Access

    Article

    Differential expression of keratin 19 in normal human epithelial tissues revealed by monospecific monoclonal antibodies

    Three monospecific monoclonal antibodies (BA16, BA17 and A53—B/A2) recognizing different epitopes of the human keratin 19 were used to determine tissue distribution of this 40 kDa keratin polypeptide. Immunohi...

    J. Bártek, J. Bártková, J. Taylor-Papadimitriou, A. Rejthar… in The Histochemical Journal (1986)