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Article
Cautionary tales of survival analysis: conflicting analyses from a clinical trial in breast cancer
Data from a completed randomized trial in breast cancer are used to demonstrate and quantify the variation in estimated survival curves and log-rank statistics at different times throughout a trial. False 'pla...
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Article
Body weight and vascular invasion in post-menopausal women with breast cancer
To examine the relationship between body weight and vascular invasion (VI) around tumours in post-menopausal women with operable breast cancer, a retrospective study was conducted of 393 patients treated in a ...
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Article
A randomised comparison of a third-generation regimen (PACEBOM) with a standard regimen (CHOP) in patients with histologically aggressive non-Hodgkin's lymphoma: a British National Lymphoma Investigation report
A combination of cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) has been a standard therapy for histologically aggressive non-Hodgkin's lymphomas for over 20 years, but several newer regime...
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Article
Mathematical modelling of tumour response in primary breast cancer
Although breast cancer is perceived to be relatively chemosensitive, cytotoxic drug therapy only leads to cure in the adjuvant setting. In advanced disease, primary resistance and inadequate cell kill may be i...
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Article
Serum progesterone and prognosis in operable breast cancer
Several studies have now shown that women with operable breast cancer undergoing tumour excision during the luteal phase of the menstrual cycle have a better prognosis than those having surgery during the foll...
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Article
Variations in the management and survival of women under 50 years with breast cancer in the South East Thames region
A retrospective, population-based study was undertaken to determine variations in the management of women aged less than 50 years with primary breast cancer in different hospital settings and the influence of ...
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Article
Burnout and psychiatric disorder among cancer clinicians
The prevalence and causes of 'burnout' and psychiatric disorder among senior oncologists and palliative care specialists have been measured in a national questionnaire-based survey. All consultant non-surgical...
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Article
The prognostic significance of DNA flow cytometry in breast cancer: results from 881 patients treated in a single centre
In this single-centre study of 881 patients, S-phase fraction (SPF) was shown to be a significant prognostic marker in terms of overall survival (OS), relapse-free survival (RFS) and survival after relapse (SA...
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Article
Expression of sialyl-Tn predicts the effect of adjuvant chemotherapy in node-positive breast cancer
Sialyl-Tn (STn) is a carcinoma-associated carbohydrate determinant expressed on cancer-associated mucins and has the structure NANA alpha(2-6)alpha GalNAc. Expression of STn in colon and ovarian cancer is asso...
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Article
A controlled trial of adjuvant tamoxifen, with or without prednisolone, in post-menopausal women with operable breast cancer
A randomised clinical trial has been conducted to compare adjuvant tamoxifen, 20 mg daily, with tamoxifen and prednisolone, 7.5 mg daily, in post-menopausal women with operable breast cancer. There were 254 ev...
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Article
Chemotherapy of advanced breast cancer: outcome and prognostic factors
The outcome for 758 consecutive patients who had received one or more chemotherapy regimens for recurrent or metastatic breast cancer is presented. The response rate following first line treatment was 34%. Med...
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Article
Spinal cord compression in breast cancer: a review of 70 cases
Spinal cord compression (SCC) is a relatively uncommon but frequently disabling complication of metastatic breast cancer. We have conducted this retrospective study of 70 patients with SCC secondary to breast ...
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Article
Advanced breast cancer: use of resources and cost implications
Little information is currently available on the use of hospital resources and the resulting costs of treating any advanced cancer. Such data may be useful for planning purposes and for calculating the cost ef...
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Article
The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer
The relationship between c-erbB-2 gene expression (assessed immunohistochemically), S-phase fraction (SPF) and prognosis has been analysed in 172 women with primary breast cancer. c-erbB-2 staining was indepen...
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Article
Using mathematical models to estimate drug resistance and treatment efficacy via CT scan measurements of tumour volume
A previously described mathematical model designed to evaluate resistance and tumour-kill for individual patients, and to predict changing tumour sizes, has been applied to patients with small cell lung cancer...
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Article
Prognostic factors for survival in stage IIIB and IV Hodgkin's disease: a multivariate analysis comparing two specialist treatment centres
A multivariate analysis of prognostic factors was carried out on 301 patients with clinical or pathological stage III/IV Hodgkin's disease treated using the same combination chemotherapy (MVPP) at two centres ...
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Article
Adjusting survival curves for imbalances in prognostic factors
A new method for comparing the survival of two or more groups of patients adjusting for factors distributed unevenly between the groups is presented. This is a development of previous methods, and provides a g...
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Article
Who should measure quality of life, the doctor or the patient?
The extent to which a doctor or health professional can make a valid assessment of a patient's quality of life, anxiety and depression was investigated in a series of cancer patients. Doctors and patients fill...
