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Article
Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication
The disialoganglioside GD2 is overexpressed on several solid tumors, and monoclonal antibodies targeting GD2 have substantially improved outcomes for children with high-risk neuroblastoma. However, approximate...
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Article
Open AccessSemaphorin 3A mediated brain tumor stem cell proliferation and invasion in EGFRviii mutant gliomas
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of approximately 15 months. Semaphorin 3A (Sema3A), known for its axon guidance and antiangiogenic propert...
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Article
Articular cartilage regeneration by activated skeletal stem cells
Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive destruction of articular cartilage1. The etiology of OA is complex and involves a variety of factors, including genetic predisp...
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Article
James L. Gowans 1924–2020
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Article
Phagocytosis checkpoints as new targets for cancer immunotherapy
Cancer immunotherapies targeting adaptive immune checkpoints have substantially improved patient outcomes across multiple metastatic and treatment-refractory cancer types. However, emerging studies have demons...
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Article
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens
Phagocytosis is required for a broad range of physiological functions, from pathogen defense to tissue homeostasis, but the mechanisms required for phagocytosis of diverse substrates remain incompletely unders...
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Article
Improving immune–vascular crosstalk for cancer immunotherapy
Normalization of the tumour vasculature can improve immune effector cell infiltration, leading to immunotherapy potentiation. In this Opinion article, Huanget al. propose that reciprocal regulation between tumour...
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Chapter
Urochordata: Botryllus – Natural Chimerism and Tolerance Induction in a Colonial Chordate
Chimerism is defined as the coexistence of two or more genomes of separate origin within an individual. In placental mammals such as humans, natural chimerism develops during pregnancy between a mother and fet...
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Article
Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy
Exciting progress in the field of cancer immunotherapy has renewed the urgency of the need for basic studies of immunoregulation in both adaptive cell lineages and innate cell lineages. Here we found a central...
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Article
Lessons from immuno-oncology: a new era for cancer nanomedicine?
Despite a decade of intensive preclinical research, the translation of cancer nanomedicine to the clinic has been slow. Here, we discuss how recent lessons learned from the successes with immuno-oncology thera...
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Article
Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies
There is much interest in the applications of pluripotent stem cells for regenerative medicine. In this Perspective, the authors discuss the factors that might contribute to the potential risk of tumorigenicit...
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Article
Programmed cell removal: a new obstacle in the road to develo** cancer
Recent evidence indicates that successful cancer clones must have overcome programmed cell removal. In this Opinion article, the authors explore the role of programmed cell removal in both normal and neoplasti...
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Article
IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ
Pathways dependent on the transcription factor NF-κB provide innate immunity against microbes. Karin and colleagues show that mice lacking the kinase IKKβ have IL-1-dependent neutrophilia. Loss of IL-1 signali...
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Article
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
The development of a long-term intestinal culture system has, until recently, eluded researchers. Here the authors describe a method allowing long-term culture of both small intestine and colon that incorporat...
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Protocol
Generation of a Monoclonal Antibody Library Against Human Embryonic Stem Cells
Differentiated cell types derived from human embryonic stem cells (hESCs) may serve in the future to treat various human diseases and to model early human embryonic development in vitro. Fulfilling this potent...
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Article
Erratum: Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
Nat. Med. 10, 510–517 (2004). TCD bone marrow was defined in the article as “T-cell-derived” bone marrow. The correct definition is “T-cell-depleted” bone marrow. We regret the error.
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Article
Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
Skin is the most commonly affected organ in graft-versus-host disease (GVHD). To explore the role of Langerhans cells in GVHD, the principal dendritic cells of the skin, we studied the fate of these cells in m...
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Chapter and Conference Paper
Leukemia and Leukemic Stem Cells
Leukemias are cancers of the hematopoietic system. Like all cancers, several genetic and epigenetic events aid in the transition from normal to malignant cell. These usually, if not always, include at least: 1...
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Article
Initial characterization of a protochordate histocompatibility locus
The colonial protochordate, Botryllus schlosseri, undergoes a natural transplantation reaction which is controlled by a single, highly polymorphic locus called the Fu/HC. We are using map-based cloning to identif...
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Article
Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells