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Article
James L. Gowans 1924–2020
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Protocol
Methods for the Measurement of Early Events in Toxoplasma gondii Immunity in Mouse Cells
Critical steps in resistance of mice against Toxoplasma gondii occur in the first 2 or 3 h after the pathogen has entered a cell that has been exposed to interferon γ (IFNγ). The newly formed parasitophorous vacu...
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Article
Open AccessAuthor Correction: Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice
The original version of this Article contained an error in the Acknowledgements, which incorrectly omitted the following: ‘C.C., C.A., and J.C.H. were supported by the Fundação Calouste Gulbenkian through a gr...
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Article
Open AccessMolecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice
Some strains of the protozoan parasite Toxoplasma gondii (such as RH) are virulent in laboratory mice because they are not restricted by the Immunity-Related GTPase (IRG) resistance system in these mouse strains....
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Article
Open AccessLoss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection
The interferon-γ (IFN-γ)-inducible immunity-related GTPase (IRG), Irgm1, plays an essential role in restraining activation of the IRG pathogen resistance system. However, the loss of Irgm1 in mice also causes ...
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Article
The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens
The immunity-related GTPases (IRGs) belong to the family of large, interferon-inducible GTPases and constitute a cell-autonomous resistance system essential for the control of vacuolar pathogens like Toxoplasma g...
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Article
Open AccessThe activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii
The interferon-inducible immunity-related GTPases (IRG proteins/p47 GTPases) are a distinctive family of GTPases that function as powerful cell-autonomous resistance factors. The IRG protein, Irga6 (IIGP1), pa...
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Article
Open AccessSpontaneous focal activation of invariant natural killer T (iNKT) cells in mouse liver and kidney
Invariant natural killer T (iNKT) cells differ from other T cells by their hyperactive effector T-cell status, in addition to the expression of NK lineage receptors and semi-invariant T-cell receptors. It is g...
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Article
Why didn't Darwin discover Mendel's laws?
Darwin's focus on small quantitative variations as the raw material of evolution may have prevented him from discovering the laws of inheritance.
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Article
Open AccessThe interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage
Members of the p47 (immunity-related GTPases (IRG) family) GTPases are essential, interferon-inducible resistance factors in mice that are active against a broad spectrum of important intracellular pathogens. ...
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Article
Is a mutator analogous to the Ig hypermutator of the sheep ileal Peyer's patch active on MHC class I genes in the germ line?
Polymorphic sequence variation in the peptide-binding domains of MHC class I molecules appears to have been driven largely by the constructive action of natural selection on the specificity of the peptide-bin...
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Chapter
Contemplations on the Evolution of PRO- and Eukaryotic Mono(ADP-Ribosyl)Transferases in the Context of the Immune System
The mammalian cell-surface mono-ADP-ribosyltransferase, known as RT6 in the rat in which it was first uncovered (1-3), presents us with a common problem in modern biology, namely the definition of function in ...
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Article
Rat RT1 orthologs of mouse H2-M class lb genes
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Article
Isolation of a functional cDNA encoding the RT1.Au MHC class I heavy chain by a novel PCR-based method
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Article
An analysis of the antigen binding site of RT1.Aa suggests an allele-specific motif
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Article
Selectivity of MHC-encoded peptide transporters from human, mouse and rat
MAJOR histocompatibility complex (MHC) class I molecules present peptides from degraded intracellular antigens to CD8+ T cells1. These peptides are translocated in an ATP-dependent fashion2–4 into the lumen of th...
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Article
The distribution of Tap2 alleles among laboratory rat RT1 haplotypes
We are reporting the cDNA sequences of Tap2 from two cim a and two cim b rat strains. Comparison of the cDNA sequences shows that these alleles fall into two groups, which we refer to as Tap2-A and Tap2-B. We fou...
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Article
Peptides and the proteasome
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Article
Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation
MAJOR histocompatibility complex (MHC) class I molecules bind and deliver peptides derived from endogenously synthesized proteins to the cell surface for survey by cytotoxic T lymphocytes. It is believed that ...
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Article
Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule
Short antigenic peptides bound in the groove of class I major histocompatibility complex molecules enable T cells to detect intracellular pathogens. It has been assumed that structural features of the class I ...
