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Article
Open AccessRegulation of cerebral blood flow boosts precise brain targeting of vinpocetine-derived ionizable-lipidoid nanoparticles
Despite advances in active drug targeting for blood-brain barrier penetration, two key challenges persist: first, attachment of a targeting ligand to the drug or drug carrier does not enhance its brain biodist...
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Article
Open AccessResponse of treatment-naive brain metastases to stereotactic radiosurgery
With improvements in survival for patients with metastatic cancer, long-term local control of brain metastases has become an increasingly important clinical priority. While consensus guidelines recommend surge...
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Article
Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells
Intracellular DNA sensors regulate innate immunity and can provide a bridge to adaptive immunogenicity. However, the activation of the sensors in antigen-presenting cells (APCs) by natural agonists such as dou...
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Article
Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics
Nanomedicines have been approved to treat multiple human diseases. However, clinical adoption of nanoformulated agents is often hindered by concerns about hepatic uptake and clearance, a process that is not fu...
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Article
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease
Microglial involvement in Alzheimer’s disease (AD) pathology has emerged as a risk-determining pathogenic event. While apolipoprotein E (APOE) is known to modify AD risk, it remains unclear how microglial apoE im...
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Article
Open AccessDual targeted extracellular vesicles regulate oncogenic genes in advanced pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) tumours carry multiple gene mutations and respond poorly to treatments. There is currently an unmet need for drug carriers that can deliver multiple gene cargoes to targ...
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Article
Open AccessAdaptive design of mRNA-loaded extracellular vesicles for targeted immunotherapy of cancer
The recent success of mRNA therapeutics against pathogenic infections has increased interest in their use for other human diseases including cancer. However, the precise delivery of the genetic cargo to cells ...
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Article
Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy
The success of messenger RNA therapeutics largely depends on the availability of delivery systems that enable the safe, effective and stable translation of genetic material into functional proteins. Here we sh...
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Article
Engineering nanomaterial physical characteristics for cancer immunotherapy
The physical properties of nanomaterials — such as size, structure, shape, charge, mechanical strength and hydrophobicity — can directly or indirectly influence immune cell functions and modulate immune respon...
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Article
Immunological conversion of solid tumours using a bispecific nanobioconjugate for cancer immunotherapy
Solid tumours display a limited response to immunotherapies. By contrast, haematological malignancies exhibit significantly higher response rates to immunotherapies as compared with solid tumours. Among severa...
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Article
Cancer immunotherapy based on image-guided STING activation by nucleotide nanocomplex-decorated ultrasound microbubbles
The cytosolic innate immune sensor cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is crucial for priming adaptive antitumour immunity through antigen-presenting cells (APCs). Natur...
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Article
Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function
The ε4 allele of the apolipoprotein E (APOE) gene, a genetic risk factor for Alzheimer’s disease, is abundantly expressed in both the brain and periphery. Here, we present evidence that peripheral apoE isoforms, ...
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Article
Open AccessSingle-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target
A major rate-limiting step in develo** more effective immunotherapies for GBM is our inadequate understanding of the cellular complexity and the molecular heterogeneity of immune infiltrates in gliomas. Here...
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Article
Author Correction: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation
A Correction to this paper has been published: https://doi.org/10.1038/s41551-021-00725-w.
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Article
Considerations for designing preclinical cancer immune nanomedicine studies
Immunotherapy is known to be clinically beneficial for cancer patients and in many cases represents the new standard of care. Because of this success, the interest in integrating nanomedicine with cancer immun...
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Article
The role of radiation therapy in treatment of adults with newly diagnosed glioblastoma multiforme: a systematic review and evidence-based clinical practice guideline update
These recommendations apply to adult patients diagnosed with newly diagnosed glioblastoma.
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Article
Open AccessTherapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
Tumour cell phagocytosis by antigen presenting cells (APCs) is critical to the generation of antitumour immunity. However, cancer cells can evade phagocytosis by upregulating anti-phagocytosis molecule CD47. H...
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Article
Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation
Exosomes are attractive as nucleic-acid carriers because of their favourable pharmacokinetic and immunological properties and their ability to penetrate physiological barriers that are impermeable to synthetic...
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Article
Phagocytosis checkpoints as new targets for cancer immunotherapy
Cancer immunotherapies targeting adaptive immune checkpoints have substantially improved patient outcomes across multiple metastatic and treatment-refractory cancer types. However, emerging studies have demons...
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Article
Publisher Correction: On the issue of transparency and reproducibility in nanomedicine
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
