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Open AccessReply to Reasons Latesters
It is an honor to receive such careful and attentive criticism. In this response, I attempt to put the criticisms of the reasons latesters into the context of my argumentative aims in the book and to point tow...
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Open AccessPrécis of Reasons First
This is an overview of the main themes and theses of Reasons First for a book symposium, and intended to be read alongside the other contributions to that symposium.
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Experientialism Unidealized
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The fundamental reason for reasons fundamentalism
Reasons, it is often said, are king in contemporary normative theory. Some philosophers say not only that the vocabulary of reasons is useful, but that reasons play a fundamental explanatory role in normative ...
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Open AccessAurora-A kinase oncogenic signaling mediates TGF-β-induced triple-negative breast cancer plasticity and chemoresistance
Triple-negative breast cancer (TNBCs) account for 15–20% of all breast cancers and represent the most aggressive subtype of this malignancy. Early tumor relapse and progression are linked to the enrichment of ...
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Open AccessSemaphorin 3A mediated brain tumor stem cell proliferation and invasion in EGFRviii mutant gliomas
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of approximately 15 months. Semaphorin 3A (Sema3A), known for its axon guidance and antiangiogenic propert...
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Attributing error without taking a stand
Moral error theory is the doctrine that our first-order moral commitments are pervaded by systematic error. It has been objected that this makes the error theory itself a position in first-order moral theory t...
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Open AccessNOTCH3 expression is linked to breast cancer seeding and distant metastasis
Development of distant metastases involves a complex multistep biological process termed the invasion-metastasis cascade, which includes dissemination of cancer cells from the primary tumor to secondary organs. N...
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Article
Stakes, withholding, and pragmatic encroachment on knowledge
Several authors have recently endorsed the thesis that there is what has been called pragmatic encroachment on knowledge—in other words, that two people who are in the same situation with respect to truth-rela...
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Précis of Slaves of the Passions
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Reply to Shafer-Landau, Mcpherson, and Dancy
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Supervenience arguments under relaxed assumptions
When it comes to evaluating reductive hypotheses in metaphysics, supervenience arguments are the tools of the trade. Jaegwon Kim and Frank Jackson have argued, respectively, that strong and global supervenienc...
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How Not to Avoid Wishful Thinking
In 2002, Cian Dorr offered a new challenge to metaethical non-cognitivism: the wishful thinking problem. Based on considerations from epistemology, it is quite distinct from the usual problems associated with ...
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How to Be an Expressivist about Truth
In this chapter I explore why one might hope to, and how to begin to, develop an expressivist account of truth—that is, a semantics for ‘true’ and ‘false’ within an expressivist framework. I don’t mean to defe...
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Means-end coherence, stringency, and subjective reasons
Intentions matter. They have some kind of normative impact on our agency. Something goes wrong when an agent intends some end and fails to carry out the means she believes to be necessary for it, and something go...
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Having reasons
What is it to have a reason? According to one common idea, the Factoring Account, you have a reason to do A when there is a reason for you to do A which you have—which is somehow in your possession or grasp. In t...
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Continuous Technology Implementation and Sustainability of Sociotechnical Change: A Case Study of Advanced Intravenous Infusion Pump Technology Implementation in a Hospital
Recently, much public attention has been on medical errors and patient safety. Healthcare organizations are being pressured to improve their systems and processes and implement various technologies in order to...
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Predicting expression patterns from regulatory sequence in Drosophila segmentation
The establishment of complex expression patterns at precise times and locations is key to metazoan development, yet a mechanistic understanding of the underlying transcription control networks is still missing...
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Reasons and Agent-neutrality
This paper considers the connection between the three-place relation, R is a reason for X to do A and the two-place relation, R is a reason to do A. I consider three views on which the former is to be analyzed in...
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Homology-based annotation yields 1,042 new candidate genes in the Drosophila melanogaster genome
The approach to annotating a genome critically affects the number and accuracy of genes identified in the genome sequence. Genome annotation based on stringent gene identification is prone to underestimate the...
