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Article
Purification and functional characterization of novel human skeletal stem cell lineages
Human skeletal stem cells (hSSCs) hold tremendous therapeutic potential for develo** new clinical strategies to effectively combat congenital and age-related musculoskeletal disorders. Unfortunately, refined...
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Article
Open AccessSexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration
Sexually dimorphic tissues are formed by cells that are regulated by sex hormones. While a number of systemic hormones and transcription factors are known to regulate proliferation and differentiation of osteo...
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Article
Aged skeletal stem cells generate an inflammatory degenerative niche
Loss of skeletal integrity during ageing and disease is associated with an imbalance in the opposing actions of osteoblasts and osteoclasts1. Here we show that intrinsic ageing of skeletal stem cells (SSCs)2 in m...
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Article
Articular cartilage regeneration by activated skeletal stem cells
Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive destruction of articular cartilage1. The etiology of OA is complex and involves a variety of factors, including genetic predisp...
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Article
The impossible gallbladder: aspiration as an alternative to conversion
Laparoscopic cholecystectomy is the standard of care for symptomatic gallstone disease but when laparoscopic removal proves impossible the standard advice is to convert to open surgery. This jettisons the adva...
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Article
Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration
During both embryonic development and adult tissue regeneration, changes in chromatin structure driven by master transcription factors lead to stimulus-responsive transcriptional programs. A thorough understan...
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Article
Open AccessAuthor Correction: Genetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes
In the original version of this Article, the authors inadvertently omitted Elizabeth A. Brett, who contributed to the generation of the histology figures, from the author list.This has now been corrected in bo...
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Article
Open AccessGenetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes
Targeted genetic dissection of tissues to identify precise cell populations has vast biological and therapeutic applications. Here we develop an approach, through the packaging and delivery of 4-hydroxytamoxif...
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Article
Isolation and functional assessment of mouse skeletal stem cell lineage
A flow cytometry–based approach using eight surface markers is used to distinguish cells of the skeletal stem cell lineage. Renal subcapsular transplantation and in vitro colony-formation assays are also describe...
