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  1. No Access

    Chapter

    Ependymoma

    Ependymomas are the most common intramedullary tumor in adults. Patients have an indolent presentation and commonly complain of back and neck pain, with these symptoms ultimately progressing to myeloradiculopa...

    Dominique M. O. Higgins, Mychael Delgardo, Simon Hanft… in Tumors of the Spinal Canal (2021)

  2. Article

    Open Access

    Semaphorin 3A mediated brain tumor stem cell proliferation and invasion in EGFRviii mutant gliomas

    Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of approximately 15 months. Semaphorin 3A (Sema3A), known for its axon guidance and antiangiogenic propert...

    Dominique M. O. Higgins, Maisel Caliva, Mark Schroeder, Brett Carlson… in BMC Cancer (2020)

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    Chapter

    Applications of Stereotactic Radiosurgery for Brain Metastases

    Radiation therapy has been a mainstay of managing brain metastases for decades. In the past, clinicians have relied on whole brain radiotherapy (WBRT) and in some instances partial brain radiation therapy to d...

    Akshay V. Save, Dominique M. O. Higgins… in Central Nervous System Metastases (2020)

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    Chapter

    Spinal Stimulation

    Back and leg pain are among the most common primary issues seen in the United States and globally. Medical management is the mainstay of treatment, which consists of a combination of pharmaceutical treatment o...

    Akshay V. Save, Dominique M. O. Higgins… in Stereotactic and Functional Neurosurgery (2020)