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Article
Open AccessThe combination of arsenic, interferon-alpha, and zidovudine restores an “immunocompetent-like” cytokine expression profile in patients with adult T-cell leukemia lymphoma
HTLV-I associated adult T-cell leukemia/lymphoma (ATL) carries a dismal prognosis due to chemo-resistance and immuno-compromised micro-environment. The combination of zidovudine and interferon-alpha (IFN) sign...
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Article
Open AccessThe combination of arsenic, interferon-alpha, and zidovudine restores an “immunocompetent-like” micro-environment in patients with adult T-cell leukemia lymphoma
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Article
Modified Irinotecan Plus Cisplatin and Dexamethasone (ICD) Combination Chemotherapy as Salvage Chemotherapy for Patients with Relapsed/Refractory Diffuse Large Cell Lymphoma
About 50 % of patients with diffuse large cell lymphoma are candidate for salvage chemotherapy followed by bone marrow transplantation in the selected patients. In the current study we evaluated modified ICD (...
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Article
JAK2 V617F Mutation in Adult T Cell Leukemia-Lymphoma
Adult T cell Leukemia/lymphoma (ATL) is a mature T-cell neoplasm that has strong association with the human T-lymphotropic virus type 1 (HTLV-I) infection. This infection is endemic in our region (north easter...
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Article
Assessment of HTLV-1 proviral load, LAT, BIM, c-FOS and RAD51 gene expression in adult T cell leukemia/lymphoma
Adult T cell leukemia/lymphoma (ATLL) is a life-threatening malignancy of HTLV-1 infected Th lymphocytes. In the present study host–virus interactions were investigated by assessment of HTLV-1 proviral load (P...
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Article
Open AccessHTLV-1-host interactions on the development of adult T cell leukemia/lymphoma: virus and host gene expressions
Adult T-cell leukemia/lymphoma (ATLL) is a lymphoproliferative disorder of HTLV-1-host interactions in infected TCD4+ cells. In this study, the HTLV-1 proviral load (PVL) and HBZ as viral elements and AKT1, BAD,
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Article
Structural reliability approach to analysis of probabilistic seismic hazard and its sensitivities
This paper presents a new probabilistic framework for seismic hazard assessment and hazard sensitivity analysis. Hazard in this context means the probability of exceeding a measure of ground shaking intensity,...
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Article
Probabilistic seismic hazard analysis of Iran using reliability methods
Structural reliability methods are employed in this paper for nationwide probabilistic seismic hazard analysis of Iran and in-depth seismic hazard and hazard sensitivity analysis of Downtown Tehran. The compan...
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Chapter
Albumin-Based Carriers for Systemic Delivery to Tackle Cancer
Proteins have been used to fabricate and design carriers for systemic drug delivery. One of the proteins that shows great potential for the applications in systemic delivery is albumin which is the most abunda...
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Article
Open AccessEffect of hydroxychloroquine on COVID-19 prevention in cancer patients undergoing treatment: a structured summary of a study protocol for a randomised controlled trial
In this study, we investigate the effect of hydroxychloroquine on the prevention of Novel Coronavirus Disease (COVID-19) in cancer patients being treated.
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Article
Investigating the association between rs6983267 polymorphism and susceptibility to gastrointestinal cancers in Iranian population
Genome-wide association studies have revealed that some single nucleotide polymorphisms at 8q24, such as rs6983267, might be effective in susceptibility to various cancers in different populations. Therefore, ...
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Chapter
Radiosensitizers in Radiation-Induced Cancer Therapy
Radiation therapy (RT) has established as a very auspicious tool to tackle cancer, but its efficacy has encountered with some challenges. As we all know, in the case of cancer therapy by RT, high doses of radi...
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Article
Aprepitant, fosaprepitant and risk of ifosfamide-induced neurotoxicity: a systematic review
Ifosfamide is one of the chemotherapy regimens which potentially causes neurotoxicity in patients up to 30%. Aprepitant is administered as an anti-emetic agent in chemotherapy and regarding the inhibitory effe...
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Article
The Bovine Serum Albumin Coated Copper Oxide Nanoparticle for Curcumin Delivery in Biological Environment: In-vitro Drug Release
The copper oxide nanoparticles (CuO NPs) were synthesized by a simple method and then coated with the bovine serum albumin (BSA) to form CuO@BSA NPs. Finally, curcumin (CUR) as an anticancer drug was loaded to...
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Article
BSA-PEI Nanoparticle Mediated Efficient Delivery of CRISPR/Cas9 into MDA-MB-231 Cells
The discovery of bacterial-derived Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system has revolutionized genome engineering and gene therapy due to its...
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Article
Gene expression study of host-human T-cell leukaemia virus type 1 (HTLV-1) interactions: adult T-cell leukaemia/lymphoma (ATLL)
In HTLV-1-associated malignant disease, adult T-cell leukaemia/lymphoma (ATLL), the interaction of virus and host was evaluated at the chemokines gene expression level. Also, IL-1β and Caspase-1 expressions were ...
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Article
Kerr nonlinear effect in the graphene-based wedged hybrid plasmonic waveguide
The plasmonic nanostructures optical properties, both linear and nonlinear, offer valuable insights for designing nanoscale all-optical devices with rapid response times. This study proposes a novel plasmonic ...
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Article
Comparison of bolus administration and short-term infusion versus long-term infusion of doxorubicin in terms of cardiotoxicity and efficacy
Cardiotoxicity caused by anthracyclines chemotherapy is one of the leading causes of mortality and morbidity in cancer survivors. Continuous infusion (CI) instead of bolus (BOL) injection is one of the methods...
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Article
The evaluation of atorvastatin as an adjunct to fluconazole for the anti-fungal prophylaxis in acute myeloid leukemia: a multicenter, triple-blinded, randomized clinical trial
The development of invasive fungal infections (IFIs) is a serious complication in acute myeloid leukemia (AML) patients who undergo an induction to remission chemotherapy. Given the increased mortality in AML ...
