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The Bovine Serum Albumin Coated Copper Oxide Nanoparticle for Curcumin Delivery in Biological Environment: In-vitro Drug Release

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Abstract

The copper oxide nanoparticles (CuO NPs) were synthesized by a simple method and then coated with the bovine serum albumin (BSA) to form CuO@BSA NPs. Finally, curcumin (CUR) as an anticancer drug was loaded to the CuO@BSA NPs. The characterization of nanoparticles was carried out by Fourier-transport infrared (FT-IR), ultraviolet-visible (UV-vis), transmission electron microscopy (TEM), and atomic force microscopy (AFM) analysis. It was found that the synthesized CuO@BSA-CUR nanoparticles were spherical with a particle size of 20–30 nm. Also, the result of drug release in the biological environment showed that maximum drug release for this nanocarrier in pH of 7.4 was measured 72% after 48 h. The cytotoxicity of CuO@BSA-CUR against the MDA-MB-231 breast cancer cell line was studied by MTT assay test. The results indicated that CuO@BSA-CUR nanoparticles have a remarkable anticancer effect on breast cancer cell line.

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Acknowledgements

The work presented here is the result of the Master’s thesis of Tahmineh Atloo with No. 33131 from the University of Zanjan. The authors would like to thank various people for their contribution to this work, their valuable technical support on this work, and their help in the collection of plant data, and also all the technicians who helped in handling the instruments. Also, the authors gratefully acknowledge Zanjan University of Medical Sciences for this research work.

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Authors and Affiliations

  1. Department of Physics, Faculty of Science, University of Zanjan, 45371-38791, Zanjan, Iran

    Tahmineh Atloo & Ramin Mohammadkhani

  2. Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

    Ali Mohammadi, Hamed Nosrati & Hosein Danafar

  3. Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran

    Hamed Nosrati & Hosein Danafar

  4. Department of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

    Kasra Arbabi Zaboli, Saeed Kaboli & Hossein Rahimi

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  1. Tahmineh Atloo
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  2. Ramin Mohammadkhani
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  3. Ali Mohammadi
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Correspondence to Ramin Mohammadkhani or Hosein Danafar.

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Atloo, T., Mohammadkhani, R., Mohammadi, A. et al. The Bovine Serum Albumin Coated Copper Oxide Nanoparticle for Curcumin Delivery in Biological Environment: In-vitro Drug Release. J Polym Environ 30, 3203–3208 (2022). https://doi.org/10.1007/s10924-022-02401-9

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  • DOI: https://doi.org/10.1007/s10924-022-02401-9

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