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Article
Synthesis of novel GABA-Triazole tethered derivatives of Noscapine and their anticancer activities
Synthesis of novel noscapine triazole tethered derivatives with γ-aminobutyric acid (GABA) linker is reported. Attachment of the linker was done by N-demethylation of noscapine followed by coupling with N-Boc pro...
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Article
Diabetes and ovarian cancer: risk factors, molecular mechanisms and impact on prognosis
Diabetes mellitus has been linked to a lower rate of cancer survival and an increase in the incidence of most malignancies. Investigations showed that diabetes might affect ovarian cancer (OC) prognosis and su...
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Article
Liquid biopsy in ovarian cancer: advantages and limitations for prognosis and diagnosis
Ovarian cancer (OC) is a highly fatal gynecologic malignancy, often diagnosed at an advanced stage which presents significant challenges for disease management. The clinical application of conventional tissue ...
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Article
Evaluation of the gene encoding carnitine transporter (OCTN2/SLC22A5) expression in human breast cancer and its association with clinicopathological characteristics
Fatty acid oxidation (FAO) is a major energy-generating process in the mitochondria and supports proliferation, growth, and survival of cancer cells. l-Carnitine is an essential co-factor for carrying long-chain ...
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Article
Pathological Mechanisms Induced by TRPM2 Ion Channels Activation in Renal Ischemia-Reperfusion Injury
Renal ischemia-reperfusion (IR) injury triggers a cascade of signaling reactions involving an increase in Ca2 + charge and reactive oxygen species (ROS) levels resulting in necrosis, inflammation, apoptosis, and ...
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Article
Review article epithelial to mesenchymal transition‑associated microRNAs in breast cancer
Despite major advances, breast cancer (BC) is the most commonly diagnosed carcinoma and remains a deadly disease among women worldwide. Many researchers point toward an important role of an epithelial to mesen...
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Article
Open AccessThe barriers to whole-grain consumption among Iranian students
Studies show that regularly consuming whole grains reduce the risk of obesity and a wide range of chronic diseases. Despite this, studies reveal that students are consuming fewer whole grains. In the present s...
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Article
Investigating the association between rs6983267 polymorphism and susceptibility to gastrointestinal cancers in Iranian population
Genome-wide association studies have revealed that some single nucleotide polymorphisms at 8q24, such as rs6983267, might be effective in susceptibility to various cancers in different populations. Therefore, ...
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Article
A novel one-pot three-component approach to 4-amino-functionalized spiropyrimidine-2-thiones
A series of 4-amino-functionalized spiropyrimidine-2-thione derivatives were simply produced by the one-pot three-component reaction of alicyclic carbonyl compounds, nitriles containing an acidic methylene, an...
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Article
Open AccessEfficacy and safety of Samtropin™ recombinant human growth hormone; a double-blind randomized clinical trial
Recombinant human growth hormone (rhGH) can increase the growth rate in growth hormone deficient children (GHD). In this randomized clinical trial, we compared the efficacy and side effects of an Iranian brand...
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Article
Open AccessVitamin D status in mothers and their newborns in Iran
Adequate vitamin D concentrations during pregnancy are necessary to neonatal calcium homeostasis, bone maturation and mineralization. The aim of study is to evaluate serum vitamin D concentrations in mothers a...
