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Article
Selective degradation of splicing factor CAPERα by anticancer sulfonamides
A series of sulfonamides induced the ubiquitin-mediated degradation of the U2AF-related splicing factor, coactivator of activating protein-1 and estrogen receptor α (CAPERα), by promoting direct binding betwee...
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Chapter
CT Coronary and Myocardial Images in Patients with Coronary Artery Lesions
Coronary computed tomographic angiography (CCTA) is a next-generation modality that can be used instead of coronary catheterization. It can be useful in evaluating coronary artery lesions after Kawasaki diseas...
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Article
Open AccessReassessment of carotid intima-media thickness by standard deviation score in children and adolescents after Kawasaki disease
Previous studies that used carotid ultrasound have been largely conflicting in regards to whether or not patients after Kawasaki disease (KD) have a greater carotid intima-media thickness (CIMT) than controls....
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Article
Open AccessJapanese consensus guidelines for pediatric nuclear medicine
The Japanese Society of Nuclear Medicine has recently published the consensus guidelines for pediatric nuclear medicine. This article is the English version of the guidelines. Part 1 proposes the dose optimiz...
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Article
Successful control of life-threatening polymorphic ventricular tachycardia by radiofrequency catheter ablation in an infant
We present a case of a 9-month-old girl in whom malignant polymorphic ventricular tachycardia (VT) was successfully controlled by radiofrequency catheter ablation under guidance with a three-dimensional mappin...
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Chapter and Conference Paper
Asymmetrical Changes in Cerebral Blood Oxygenation Induced by an Active Standing Test in Children with Postural Tachycardia Syndrome
Near-infrared spectroscopy enables recognition of various brain conditions based on certain factors, such as oxygenated hemoglobin (oxy-Hb). Since July 2012, we have been trying to determine the mechanisms of ...
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Article
Improvement in non-tachycardia-induced cardiac failure after radiofrequency catheter ablation in a child with a right-sided accessory pathway
A 6-year-old boy was referred for an evaluation of intolerance to physical activity at his elementary school. The patient had no episodes of palpitations. He was diagnosed as Wolff-Parkinson-White syndrome wit...
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Article
Successful delivery following intracytoplasmic sperm injection with calcium ionophore A23187 oocyte activation in a partially globozoospermic patient
To describe a successful pregnancy outcome following intracytoplasmic sperm injection (ICSI) with assisted oocyte activation (AOA) in a case of partial globozoospermia.
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Article
Erratum to: Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (GLP-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin
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Article
Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (GLP-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin
We recently reported that the administration of miglitol alone just before breakfast improved postprandial hyperglycemia and increased active glucagon-like peptide-1 (GLP-1) levels after lunch in men without d...
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Article
Metronomic treatment of malignant glioma xenografts with irinotecan (CPT-11) inhibits angiogenesis and tumor growth
Irinotecan (CPT-11) has shown emerging promise in the treatment of malignant gliomas. It is believed the mechanism of action of irinotecan is to sensitize glioma cells to the cytotoxic action of radiation ther...
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Article
Fungal Metabolite, Epoxyquinol B, Crosslinks Proteins by Epoxy-thiol Conjugation
Epoxyquinol B (EPQB) is a fungal metabolite, containing two α,β-epoxy ketones. We previously showed that EPQB inhibited the signal transduction involved in angiogenesis through the binding to cysteine residues...
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Article
Anti-angiogenic effects of SN38 (active metabolite of irinotecan): inhibition of hypoxia-inducible factor 1 alpha (HIF-1α)/vascular endothelial growth factor (VEGF) expression of glioma and growth of endothelial cells
Inhibition of angiogenesis is an important new treatment modality for malignancies, including gliomas. Vascular endothelial growth factor (VEGF) and hypoxia inducible factor-1α (HIF-1α) have been investigated...
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Article
Angiogenesis and antiangiogenic therapy for malignant gliomas
Angiogenesis is crucial to the growth of malignant gliomas. Therefore, antiangiogenic therapy represents a new, promising therapeutic modality for malignant gliomas. This study was designed to define the malig...
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Chapter
An All-electron First-principles Molecular Dynamics Method and a Possibility of its Application to Atomistically Distorted Systems
First-principles molecular dynamics (MD) have attracted much current interest as an important and powerful technique to investigate short time behavior of atomic motions in relatively small size systems. Among...
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Chapter and Conference Paper
The Effect of N,N,N-Trimethylsphingosine on Reperfusion Injury
The paradoxical phenomenon of the exacerbation of myocardial injury after reintroduction of blood into the ischemic tissue of the heart is well known. It has been reported that in the relatively short time fro...
