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Article
Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene
We found that the protein synthesis inhibitor hygromycin B induced the production of secondary metabolites, including lucilactaene, NG-391, fusarubin, 1233A, and 1233B, in the filamentous fungus, Fusarium sp. RK9...
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Article
RK-270A−C, new oxindole derivatives isolated from a microbial metabolites fraction library of Streptomyces sp. RK85-270
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Article
RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening
Two novel quinomycin derivatives, RK-1355A (1) and B (2), and one known quinomycin derivative, UK-63,598 (3), were isolated from a microbial metabolites fraction library of Streptomyces sp. RK88-1355 based on Nat...
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Article
Pyrrolizilactone, a new pyrrolizidinone metabolite produced by a fungus
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Article
Open AccessIsolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74
Although all Streptomyces strains are now thought to have 20–30 gene clusters for secondary metabolite biosynthesis, we cannot actually identify so many kinds of metabolites from one strain by conventional method...
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Article
Creation of novel reveromycin derivatives by alcohol-added fermentation
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Article
Spirotoamides A and B, novel 6,6-spiroacetal polyketides isolated from a microbial metabolite fraction library
Two new 6,6-spiroacetal polyketides, spirotoamides A (1) and B (2), were isolated from a microbial metabolite fraction library of Streptomyces griseochromogenes JC82-1223 by screening of structurally unique compo...
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Article
Furaquinocins I and J: novel polyketide isoprenoid hybrid compounds from Streptomyces reveromyceticus SN-593
Two novel furaquinocin (FQ) analogues, I (1) and J (2), were isolated from Streptomyces reveromyceticus SN-593 strain NRM2. Their structures were elucidated by MS and NMR analyses. Similar to the previously descr...
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Article
Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation
Investigations of reveromycin biosynthesis, including metabolite analysis, feeding experiments and in vitro tests of enzyme function, point to a two-step mechanism for formation of the central spiroacetal, in whi...
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Article
Kerriamycin B inhibits protein SUMOylation
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Article
Fungal Metabolite, Epoxyquinol B, Crosslinks Proteins by Epoxy-thiol Conjugation
Epoxyquinol B (EPQB) is a fungal metabolite, containing two α,β-epoxy ketones. We previously showed that EPQB inhibited the signal transduction involved in angiogenesis through the binding to cysteine residues...
