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  1. No Access

    Article

    Selective degradation of splicing factor CAPERα by anticancer sulfonamides

    A series of sulfonamides induced the ubiquitin-mediated degradation of the U2AF-related splicing factor, coactivator of activating protein-1 and estrogen receptor α (CAPERα), by promoting direct binding betwee...

    Taisuke Uehara, Yukinori Minoshima, Koji Sagane, Naoko Hata Sugi… in Nature Chemical Biology (2017)

  2. No Access

    Article

    Splicing factor SF3b as a target of the antitumor natural product pladienolide

    Yoshihiko Kotake, Koji Sagane, Takashi Owa, Yuko Mimori-Kiyosue… in Nature Chemical Biology (2007)

  3. Article

    Open Access

    Deficits in spatial learning and motor coordination in ADAM11-deficient mice

    ADAM11 is a member of the ADAM gene family and is mainly expressed in the nervous system. It is thought to be an adhesion molecule, since it has a disintegrin-like domain related to cell-cell or cell-matrix in...

    Eiki Takahashi, Koji Sagane, Tohru Oki, Kazuto Yamazaki, Takeshi Nagasu… in BMC Neuroscience (2006)

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  4. Article

    Open Access

    Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice

    ADAM22 is a member of the ADAM gene family, but the fact that it is expressed only in the nervous systems makes it unique. ADAM22's sequence similarity to other ADAMs suggests it to be an integrin binder and t...

    Koji Sagane, Kazuhiro Hayakawa, Junko Kai, Tomoko Hirohashi… in BMC Neuroscience (2005)

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  5. No Access

    Article

    Quantitative mouse brain proteomics using culture-derived isotope tags as internal standards

    An important challenge for proteomics is to be able to compare absolute protein levels across biological samples1,2. Here we introduce an approach based on the use of culture-derived isotope tags (CDITs) for quan...

    Yasushi Ishihama, Toshitaka Sato, Tsuyoshi Tabata… in Nature Biotechnology (2005)

  6. No Access

    Article

    Characterization of 5′-flanking region of human aggrecanase-1 (ADAMTS4) gene

    Aggrecanase-1, also known as ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs 4), cleaves at the Glu373-Ala374 site of aggrecan, thereby indicating aggrecan degradation. It is thought that ...

    Yoshiharu Mizui, Kazuto Yamazaki, Yoshikazu Kuboi, Koji Sagane… in Molecular Biology Reports (2000)