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Article
Design, synthesis, and biological evaluation of new biaryl derivatives of cycloalkyl diacetamide bearing chalcone moiety as type II c-MET kinase inhibitors
Many human cancers have been associated with the deregulation of the mesenchymal-epithelial transition factor tyrosine kinase (MET) receptor, a promising drug target for anticancer drug discovery. Herein, we r...
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Article
Open AccessHigh-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds
Morphological profiling is an omics-based approach for predicting intracellular targets of chemical compounds in which the dose-dependent morphological changes induced by the compound are systematically compar...
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Article
Open AccessPerineal stapled prolapse resection in combination with Thiersch operation for relapsed rectal prolapse: a case report
Treatment options for complete rectal prolapse include over 100 procedures. In previous reports, operative rectal prolapse repair, regardless of the technique by perineal approach, was associated with high rec...
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Article
Fusaramin, an antimitochondrial compound produced by Fusarium sp., discovered using multidrug-sensitive Saccharomyces cerevisiae
A new compound, fusaramin (1), along with three known compounds, sambutoxin (2), N-demethylsambutoxin (3) and (−)-6-deoxyoxysporidinone (4), was isolated from a culture broth of Fusarium sp. FKI-7550 by bioassay-...
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Article
Pestiocandin, a new papulacandin class antibiotic isolated from Pestalotiopsis humus
Secondary metabolites of microorganisms have proven to be an excellent source of drugs. We isolated a new antibiotic, named pestiocandin (1), from a culture broth of a filamentous fungus, Pestalotiopsis humus FKI...
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Article
Open AccessTRPA1-dependent reversible opening of tight junction by natural compounds with an α,β-unsaturated moiety and capsaicin
The delivery of hydrophilic macromolecules runs into difficulties such as penetration of the cell membrane lipid bilayer. Our prior experiment demonstrated that capsaicin induces the reversible opening of tigh...
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Article
MA026, an anti-hepatitis C virus compound, opens tight junctions of the epithelial cell membrane
MA026 is an antiviral natural compound against hepatitis C virus (HCV). It was recently reported that MA026 binds claudin-1 (CLDN1) and inhibits HCV infection. Although CLDN1 is an important component of tight...
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Chapter
Bioprobes at a Glance
This chapter provides the fact database of bioprobes that have been reported.
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The “Bioprobes at a Glance” section is ordered alphabetically by ...
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Article
Synthesis and structure–activity relationship study of FD-891: importance of the side chain and C8–C9 epoxide for cytotoxic activity against cancer cells
Unified synthesis of FD-891 analogs and their structure–activity relationship are described. By using stereoselective allylation/crotylation and Evans aldol chemistry, six side-chain fragments having different...
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Article
Open AccessThe γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle
Inhibitors of microtubule (MT) assembly or dynamics that target α/β-tubulin are widely exploited in cancer therapy and biological research. However, specific inhibitors of the MT nucleator γ-tubulin that would...
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Article
Irciniastatin A, a pederin-type translation inhibitor, promotes ectodomain shedding of cell-surface tumor necrosis factor receptor 1
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Article
Bafilomycin L, a new inhibitor of cholesteryl ester synthesis in mammalian cells, produced by marine-derived Streptomyces sp. OPMA00072
Marine-derived Streptomyces sp. OPMA00072 was found to produce inhibitors of the synthesis of neutral lipids in a cell-based assay using Chinese hamster ovary (CHO) cells. A new 16-membered macrolide named bafilo...
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Article
Erratum: Garbled messages and corrupted translations
Nat. Chem. Biol. 6, 189–198 (2010); published online 12 February 2010; corrected after print 18 March 2010 In the version of this article initially published, the page numbers in reference 69 were incorrect. T...
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Article
Garbled messages and corrupted translations
Following transcription, genomic information begins a long journey toward translation of its nucleotide sequence into the amino acids of a protein. In eukaryotes, synthesized pre-mRNAs become processed to matu...
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Article
The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells
The 16-membered macrolide FD-891 exerts cytotoxicity toward several cancer cell lines. In this study, we showed that FD-891 induces apoptosis in various human cancer cell lines. Human leukemia Jurkat cells wer...
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Article
A cell-based screening to detect inhibitors of BRAF signaling pathway
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Article
Fungal Metabolite, Epoxyquinol B, Crosslinks Proteins by Epoxy-thiol Conjugation
Epoxyquinol B (EPQB) is a fungal metabolite, containing two α,β-epoxy ketones. We previously showed that EPQB inhibited the signal transduction involved in angiogenesis through the binding to cysteine residues...
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Chapter
Bioprobes at a Glance
