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Article
Prolonged HPA axis dysregulation in postpartum depression associated with adverse early life experiences: a cross-species translational study
Childhood and adolescent stress increase the risk of postpartum depression (PPD), often providing an increased probability of treatment refractoriness. Nevertheless, the mechanisms linking childhood and adoles...
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Article
Open AccessType 2 diabetes and cardiometabolic risk may be associated with increase in DNA methylation of FKBP5
Subclinical hypercortisolism and hypothalamic-pituitary-adrenal (HPA) axis dysfunction are associated with type 2 diabetes (T2DM), cardiovascular disease, and metabolic dysfunction. Intronic methylation of FKBP5 ...
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Article
Lack of significant association between type 2 diabetes mellitus with longitudinal change in diurnal salivary cortisol: the multiethnic study of atherosclerosis
Cross-sectional association has been shown between type 2 diabetes and hypothalamic–pituitary–adrenal (HPA) axis dysregulation; however, the temporality of this association is unknown. Our aim was to determine...
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Article
Second attempt to withdraw cabergoline in prolactinomas: a pilot study
According to Pituitary and Endocrine Society recommendations, cabergoline (CAB) therapy can be discontinued after 2 years in hyperprolactinemic patients who fit certain criteria. Previous studies found recurr...
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Article
History of childhood adversity is positively associated with ventral striatal dopamine responses to amphetamine
Childhood exposure to severe or chronic trauma is an important risk factor for the later development of adult mental health problems, such as substance abuse. Even in nonclinical samples of healthy adults, per...
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Article
Volunteerism and self-selection bias in human positron emission tomography neuroimaging research
Scientists have known for decades that persons who volunteer for behavioral research may be different from those who decline participation and that characteristics differentiating volunteers from non-volunteer...
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Article
Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adults
Chronic dysregulation of hypothalamus–pituitary–adrenal (HPA) axis activity is related to several neuropsychiatric disorders. Studies suggest that cortisol response to stress has a strong genetic etiology, and...
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Article
ACTH-secreting pituitary adenomas: size does not correlate with hormonal activity
ACTH-secreting pituitary adenomas (Cushing’s disease, CD) are the most frequent cause of Cushing’s syndrome. To test whether the size of ACTH-secreting adenomas correlates with the degree of biochemical and cl...
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Article
A measure of glucocorticoid load provided by DNA methylation of Fkbp5 in mice
Given the contribution of cortisol dysregulation to neuropsychiatric and metabolic disorders, it is important to be able to accurately compute glucocorticoid burden, a measure of allostatic load. One major pro...
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Article
Reliability of hypothalamic–pituitary–adrenal axis assessment methods for use in population-based studies
Population-based studies have been hampered in exploring hypothalamic–pituitary–adrenal axis (HPA) activity as a potential explanatory link between stress-related and metabolic disorders due to their lack of i...
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Article
Biological Basis of Depression in Adults with Diabetes
Diabetes and depression are common comorbid conditions. Although certain health behaviors and risk factors partially explain the association of depression and diabetes, other potential mechanisms have yet to b...
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Article
Differences in δ- and μ-Opioid Receptor Blockade Measured by Positron Emission Tomography in Naltrexone-Treated Recently Abstinent Alcohol-Dependent Subjects
Blockade of brain μ-opioid receptor (μ-OR) and δ-opioid receptor (δ-OR) was investigated in recently abstinent alcohol-dependent subjects (N=21) maintained on naltrexone. Subjects completed a 19-day inpatient pro...
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Article
Association of Amphetamine-Induced Striatal Dopamine Release and Cortisol Responses to Psychological Stress
Preclinical studies have shown that stress and glucocorticoids increase mesolimbic dopamine (DA) and thereby facilitate psychostimulant self-administration. The relationship between stress-induced cortisol and...
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Article
Hormonal Responses to Psychological Stress and Family History of Alcoholism
The present study was designed to determine whether stress hormones and subjective responses to a psychological stressor were different in nonalcoholic offspring from families with a history of alcohol depende...
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Article
Relationship between Cortisol Responses to Stress and Personality
Although there is growing evidence of links between the cortisol stress response and personality, the nature of the relationships and the underlying mechanisms require further clarification. The purpose of thi...
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Article
The Mu-Opioid Receptor Polymorphism A118G Predicts Cortisol Responses to Naloxone and Stress
A polymorphism in the mu-opioid receptor (MOR) (A118G) has been shown to increase β-endorphin binding affinity, theoretically placing greater inhibitory tone on hypothalamic corticotropin-releasing hormone (CRH) ...
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Article
Relationships Among Ventral Striatal Dopamine Release, Cortisol Secretion, and Subjective Responses to Amphetamine
There is evidence that stress and glucocorticoids alter drug self-administration and mesolimbic dopamine (DA) activity in preclinical models. The primary purpose of this study was to test the hypothesis that g...
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Article
Polymorphism of the gene encoding the alpha subunit of the stimulatory G-protein of adenylyl cyclase (GNAS1)
A two-allele polymorphism of the human gene encoding for the alpha subunit of the guanine nucleotide-binding protein is described.
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Alterations in Hypothalamo-Hypophyseal Function by Ethanol
Alcoholism is a disorder characterized by a persistent and progressive pattern of ethanol ingestion which, over time, results in the loss of control over drinking and a narrowing of interests in activities oth...
