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Article
Correction: Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility
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Article
Prolonged HPA axis dysregulation in postpartum depression associated with adverse early life experiences: a cross-species translational study
Childhood and adolescent stress increase the risk of postpartum depression (PPD), often providing an increased probability of treatment refractoriness. Nevertheless, the mechanisms linking childhood and adoles...
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Article
Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility
We report a mechanism that underlies stress-induced cognitive inflexibility at the molecular level. In a mouse model under subacute cellular stress in which deficits in rule shifting tasks were elicited, the n...
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Article
Open AccessAdolescent stress impairs postpartum social behavior via anterior insula-prelimbic pathway in mice
Adolescent stress can be a risk factor for abnormal social behavior in the postpartum period, which critically affects an individual social functioning. Nonetheless, the underlying mechanisms remain unclear. U...
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Article
Open AccessElevated body fat increases amphetamine accumulation in brain: evidence from genetic and diet-induced forms of adiposity
Despite the high prevalence of obesity, little is known about its potential impact on the pharmacokinetics of psychotropic drugs. In the course of investigating the role of the microRNA system on neuronal sign...
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Article
From population to neuron: exploring common mediators for metabolic problems and mental illnesses
Major mental illnesses such as schizophrenia (SZ) and bipolar disorder (BP) frequently accompany metabolic conditions, but their relationship is still unclear, in particular at the mechanistic level. We implem...
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Article
Open AccessIncreased novelty-induced locomotion, sensitivity to amphetamine, and extracellular dopamine in striatum of Zdhhc15-deficient mice
Novelty-seeking behaviors and impulsivity are personality traits associated with several psychiatric illnesses including attention deficits hyperactivity disorders. The underlying neural mechanisms remain poor...
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Article
Host–parasite interaction associated with major mental illness
Clinical studies frequently report that patients with major mental illness such as schizophrenia and bipolar disorder have co-morbid physical conditions, suggesting that systemic alterations affecting both bra...
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Article
Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable mice
Stress during the adolescent period influences postnatal maturation and behavioral patterns in adulthood. Adolescent stress-induced molecular and functional changes in neurons are the key clinical features of ...
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Article
Open AccessInterneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory–inhibitory synapse formation in the mature cortex
Neuregulin-1 (NRG1) and its receptor ErbB4 influence several processes of neurodevelopment, but the mechanisms regulating this signalling in the mature brain are not well known. DISC1 is a multifunctional scaf...
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Article
Usp46, encoding a ubiquitin specific peptidase, is a quantitative trait gene underlying “behavioral despair” in mice
CS mice exhibit several distinct phenotypes of circadian behavioral rhythms and sleep properties. Because many mental illnesses are associated with abnormalities in the circadian rhythms and sleep pattern, we ...
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Article
Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests
Shizufumi Ebihara and colleagues report the identification of Usp46 as a quantitative trait gene underlying mouse behavior in the tail suspension and forced swimming tests, which are widely used for assessing dep...
