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Article
Longitudinal changes in brain metabolites in healthy controls and patients with first episode psychosis: a 7-Tesla MRS study
Seven Tesla magnetic resonance spectroscopy (7T MRS) offers a precise measurement of metabolic levels in the human brain via a non-invasive approach. Studying longitudinal changes in brain metabolites could he...
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Article
Psychiatric comorbidity in the Baltimore ECA follow-up study: the matrix approach
Psychiatric comorbidity is defined as the joint occurrence of two or more mental or substance use disorders. Widespread psychiatric comorbidity has been reported in treatment and population-based studies. The ...
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Article
Map** genomic loci implicates genes and synaptic biology in schizophrenia
Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 con...
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Article
Open AccessSex-specific involvement of the Notch–JAG pathway in social recognition
Under the hypothesis that olfactory neural epithelium gene expression profiles may be useful to look for disease-relevant neuronal signatures, we examined microarray gene expression in olfactory neuronal cells...
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Article
A multimodal study of a first episode psychosis cohort: potential markers of antipsychotic treatment resistance
Treatment resistant (TR) psychosis is considered to be a significant cause of disability and functional impairment. Numerous efforts have been made to identify the clinical predictors of TR. However, the explo...
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Article
De novo variation in bipolar disorder
Bipolar disorder (BD) is a common, highly heritable disorder that affects 1–2% of the world’s population. To date, most genetic studies of BD have focused on common gene variation, and while robustly associate...
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Article
Exome sequencing in obsessive–compulsive disorder reveals a burden of rare damaging coding variants
Obsessive–compulsive disorder (OCD) affects 1–2% of the population, and, as with other complex neuropsychiatric disorders, it is thought that rare variation contributes to its genetic risk. In this study, we p...
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Article
Open AccessGenome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder
Using a novel trait-based measure, we examined genetic variants associated with obsessive-compulsive (OC) traits and tested whether OC traits and obsessive-compulsive disorder (OCD) shared genetic risk. We con...
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Article
Examination of the shared genetic basis of anorexia nervosa and obsessive–compulsive disorder
Anorexia nervosa (AN) and obsessive–compulsive disorder (OCD) are often comorbid and likely to share genetic risk factors. Hence, we examine their shared genetic background using a cross-disorder GWAS meta-ana...
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Article
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
The CNV analysis group of the Psychiatric Genomic Consortium analyzes a large schizophrenia cohort to examine genomic copy number variants (CNVs) and disease risk. They find an enrichment of CNV burden in case...
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Article
Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adults
Chronic dysregulation of hypothalamus–pituitary–adrenal (HPA) axis activity is related to several neuropsychiatric disorders. Studies suggest that cortisol response to stress has a strong genetic etiology, and...
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Article
Cognitive Impairment in the Non-elderly: Validation of a New Tool to Assess Intellectual Disability in Community and Clinical Populations
In the absence of dementia or delirium, cognitive impairment in non-elderly adults is most often associated with intellectual or developmental disability. There is limited information about the prevalence of i...
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Article
Relationship between Cortisol Responses to Stress and Personality
Although there is growing evidence of links between the cortisol stress response and personality, the nature of the relationships and the underlying mechanisms require further clarification. The purpose of thi...
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Article
Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21
Schizophrenia is a common disorder characterized by psychotic symptoms; diagnostic criteria have been established1. Family, twin and adoption studies suggest that both genetic and environmental factors influence ...
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Article
Schizophrenia susceptibility and chromosome 6p24–22
