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Article
Open AccessClassifying and clustering mood disorder patients using smartphone data from a feasibility study
Differentiating between bipolar disorder and major depressive disorder can be challenging for clinicians. The diagnostic process might benefit from new ways of monitoring the phenotypes of these disorders. Sma...
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Article
The association between lithium use and neurocognitive performance in patients with bipolar disorder
Lithium remains the gold standard for the treatment of bipolar disorder (BD); however, its use has declined over the years mainly due to the side effects and the subjective experience of cognitive numbness rep...
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Article
Genome-wide association study identifies 30 loci associated with bipolar disorder
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 v...
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Article
Open AccessDetecting significant genotype–phenotype association rules in bipolar disorder: market research meets complex genetics
Disentangling the etiology of common, complex diseases is a major challenge in genetic research. For bipolar disorder (BD), several genome-wide association studies (GWAS) have been performed. Similar to other ...
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Article
Relationship between Cortisol Responses to Stress and Personality
Although there is growing evidence of links between the cortisol stress response and personality, the nature of the relationships and the underlying mechanisms require further clarification. The purpose of thi...
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Article
Testing groups of genomic locations for enrichment in disease loci using linkage scan data: A method for hypothesis testing
Genes for complex disorders have proven hard to find using linkage analysis. The results rarely reach the desired level of significance and researchers often have failed to replicate positive findings. There i...
