130 Result(s)
within
David J Hunter
English
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Article
Bone loss: Epidemiology of bone loss
Bone loss occurs when the cellular events of bone formation are quantitatively larger than bone formation. This manuscript discusses the measurement of bone loss, occurrence in the population, risk factors and...
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Article
Polymorphic repeat in AIB1 does not alter breast cancer risk
We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no a...
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Article
Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case–control study
The ataxia telangiectasia mutated (ATM) gene is a tumor suppressor gene with functions in cell cycle arrest, apoptosis, and repair of DNA double-strand breaks. Based on family studies, women heterozygous for muta...
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Article
The progesterone receptor Val660→Leu polymorphism and breast cancer risk
Recent evidence suggests a role for progesterone in breast cancer development and tumorigenesis. Progesterone exerts its effect on target cells by interacting with its receptor; thus, genetic variations, which...
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Article
Open AccessHaplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer
Truncation mutations in the BRCA1 gene cause a substantial increase in risk of breast cancer. However, these mutations are rare in the general population and account for little of the overall incidence of sporadi...
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Open AccessBody fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study
Body mass index (BMI) during adulthood is inversely related to the incidence of premenopausal breast cancer, but the role of body fatness earlier in life is less clear. We examined prospectively the relation b...
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Article
Open AccessGene × Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study
Germ-line mutations in genes such as BRCA1, BRCA2, and ATM can cause a substantial increase in risk of breast cancer. However, these mutations are rare in the general population, and account for little of the inc...
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Open AccessA comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
Androgens have been hypothesised to influence risk of breast cancer through several possible mechanisms, including their conversion to estradiol or their binding to the oestrogen receptor and/or androgen recep...
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Open AccessA polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study
Prostaglandins are integral components in the cellular response to inflammation, promoting cellular proliferation and angiogenesis. The enzyme responsible for the conversion of arachidonic acid to prostaglandi...
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Article
Open AccessCommon genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study
Mammographic density is one of the strongest risk factors for breast cancer and is believed to represent epithelial and stromal proliferation. Because of the high heritability of breast density, and the role o...
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Article
Open AccessThe association between patellar alignment on magnetic resonance imaging and radiographic manifestations of knee osteoarthritis
The aim of our study was to evaluate the association between patellar alignment by using magnetic resonance imaging images and radiographic manifestations of patello-femoral osteoarthritis (OA). Subjects were ...
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Article
Open AccessTGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study
Transforming growth factor beta 1 (TGFB1) forms a signaling complex with transforming growth factor beta receptors 1 and 2 and has been described as both a tumor suppressor and tumor promoter. Single nucleotid...
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Article
Open AccessCartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study
We used data from a longitudinal observation study to determine whether markers of cartilage turnover could serve as predictors of cartilage loss on magnetic resonance imaging (MRI). We conducted a study of da...
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Article
Open AccessThe effects of hip muscle strengthening on knee load, pain, and function in people with knee osteoarthritis: a protocol for a randomised, single-blind controlled trial
Lower limb strengthening exercises are an important component of the treatment for knee osteoarthritis (OA). Strengthening the hip abductor and adductor muscles may influence joint loading and/or OA-related sy...
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Article
Open AccessBreast cancer susceptibility loci and mammographic density
Recently, the Breast Cancer Association Consortium (BCAC) conducted a multi-stage genome-wide association study and identified 11 single nucleotide polymorphisms (SNPs) associated with breast cancer risk. Give...
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Open AccessBiochemical markers of bone turnover and their association with bone marrow lesions
Our objective was to determine whether markers of bone resorption and formation could serve as markers for the presence of bone marrow lesions (BMLs).
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Article
Open AccessComprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers
Recently, genome-wide association studies have identified loci across a segment of chromosome 8q24 (128,100,000–128,700,000) associated with the risk of breast, colon and prostate cancers. At least three regio...
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Article
Open AccessBone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized
Although the presence of bone marrow lesions (BMLs) on magnetic resonance images is strongly associated with osteoarthritis progression and pain, the underlying pathology is not well established. The aim of th...
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Article
Open AccessGenetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study
The human fibroblast growth factor (FGF) and its receptor (FGFR) play an important role in tumorigenesis. Deregulation of the FGFR2 gene has been identified in a number of cancer sites. Overexpression of the FGFR...
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Article
Open AccessA functional difficulty and functional pain instrument for hip and knee osteoarthritis
The objectives of this study were to develop a functional outcome instrument for hip and knee osteoarthritis research (OA-FUNCTION-CAT) using item response theory (IRT) and computer adaptive test (CAT) methods...
