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Article
Ambient air pollution and brain cancer mortality
Growing evidence that ultrafine particles in ambient air can cause brain lesions in animals led us to investigate whether particulate components of air pollution may be associated with brain cancer risk in hum...
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Article
Family history of various cancers and pancreatic cancer mortality in a large cohort
A family history of pancreatic cancer is associated with increased risk of pancreatic cancer, but uncertainty remains about the magnitude of this association, whether it varies by age or smoking and whether a ...
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Article
Open AccessSerum 25-hydroxyvitamin D concentrations and postmenopausal breast cancer risk: a nested case control study in the Cancer Prevention Study-II Nutrition Cohort
Vitamin D status measured during adulthood has been inversely associated with breast cancer risk in some, but not all, studies. Vitamin D has been hypothesized to prevent breast cancer through genomic and non-...
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Article
Open AccessGenetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
Gonadotropin releasing hormone (GNRH1) triggers the release of follicle stimulating hormone and luteinizing hormone from the pituitary. Genetic variants in the gene encoding GNRH1 or its receptor may influence...
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Article
Use of blood-pressure-lowering medication and risk of prostate cancer in the Cancer Prevention Study II Nutrition Cohort
To examine the association between use of anti-hypertensive drugs and prostate cancer incidence among 48,389 men in the Cancer Prevention Study II Nutrition Cohort.
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Article
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2
Douglas Easton and colleagues report results of a large multistage genome-wide association study of breast cancer. The study identifies two new breast cancer risk loci on chromosomes 3p24 and 17q23.2.
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Article
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
David Hunter and colleagues report results of the CGEMS multistage genome-wide association study of breast cancer. They identify two new risk variants on chromosomes 1p11.2 and 14q24.1, and confirm several pre...
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Article
A prospective study of waist circumference and body mass index in relation to colorectal cancer incidence
To study the association between waist circumference and colorectal cancer, and whether it is independent of body mass index (BMI).
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Article
Open AccessGenetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II
Obesity has consistently been associated with postmenopausal breast cancer risk. Proteins that are secreted by adipose tissue or are involved in regulating body mass may play a role in breast tumor development.
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Article
Multiple loci identified in a genome-wide association study of prostate cancer
We followed our initial genome-wide association study (GWAS) of 527,869 SNPs on 1,172 individuals with prostate cancer and 1,157 controls of European origin—nested in the Prostate, Lung, Colorectal, and Ovaria...
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Article
Lack of evidence for effect modification by estrogen of association between body mass index and colorectal cancer risk among postmenopausal women
Previous studies of the association between body mass index (BMI) and colorectal cancer among women found increased risk only among women who were premenopausal or used hormone replacement therapy (HRT). These...
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Article
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
We conducted a genome-wide association study (GWAS) of breast cancer by genoty** 528,173 SNPs in 1,145 postmenopausal women of European ancestry with invasive breast cancer and 1,142 controls. We identified ...
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Article
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Recently, common variants on human chromosome 8q24 were found to be associated with prostate cancer risk. While conducting a genome-wide association study in the Cancer Genetic Markers of Susceptibility projec...
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Article
Glycemic load, glycemic index, and carbohydrate intake in relation to pancreatic cancer risk in a large US cohort
Consumption of diets with high glycemic load has been hypothesized to increase pancreatic cancer risk by raising postprandial glucose levels and insulin secretion.
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Article
Open AccessVitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study
Vitamin D receptor (VDR) polymorphisms have been inconsistently associated with breast cancer risk. Whether risk is influenced by polymorphisms in other vitamin D metabolism genes and whether calcium or vitami...
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Article
Open AccessA comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
Androgens have been hypothesised to influence risk of breast cancer through several possible mechanisms, including their conversion to estradiol or their binding to the oestrogen receptor and/or androgen recep...
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Article
Open AccessPolymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort
Vascular endothelial growth factor (VEGF) plays a central role in promoting angiogenesis and is over-expressed in breast cancer. At least four polymorphisms in the VEGF gene have been associated with changes in V...
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Article
Open AccessA prospective study of XRCC1(X-ray cross-complementing group 1) polymorphisms and breast cancer risk
The gene XRCC1 (X-ray repair cross-complementing group 1) encodes a protein involved in DNA base excision repair. Two non-synonymous polymorphisms in XRCC1 (Arg194Trp and Arg399Gln) have been shown to alter DNA r...
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Article
Parity, Other Reproductive Factors, and Risk of Pancreatic Cancer Mortality in a Large Cohort of U.S. Women (United States)
Several studies have found an inverse relationship between parity and risk of pancreatic cancer. However, most of the studies of pancreatic cancer in relation to parity and other reproductive factors have been...
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Article
Use of multivitamins and prostate cancer mortality in a large cohort of US men
Objective: To assess the association between the use of multivitamins and prostate cancer mortality.
