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Article
Open AccessCosts associated with insufficient physical activity in Germany: cross-sectional results from the baseline examination of the German national cohort (NAKO)
Insufficient physical activity (PA) is a leading risk factor for non-communicable diseases posing a significant economic burden to healthcare systems and societies. The study aimed to examine the differences i...
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Article
Open AccessChildhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO)
Multiple Sclerosis (MS) represents the most common inflammatory neurological disease causing disability in early adulthood. Childhood and adolescence factors might be of relevance in the development of MS. We ...
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Article
Open AccessLarge-scale assessment of physical activity in a population using high-resolution hip-worn accelerometry: the German National Cohort (NAKO)
Large population-based cohort studies utilizing device-based measures of physical activity are crucial to close important research gaps regarding the potential protective effects of physical activity on chroni...
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Article
Open AccessBreast composition during and after puberty: the Chilean Growth and Obesity Cohort Study
Breast density (BD) is a strong risk factor for breast cancer. Little is known about how BD develops during puberty. Understanding BD trajectories during puberty and its determinants could be crucial for promo...
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Article
Open AccessChanges in physical activity and sedentary behavior during the first COVID-19 pandemic- restrictions in Germany: a nationwide survey
The COVID-19 pandemic restrictions posed challenges to maintaining healthy lifestyles and physical well-being. During the first mobility restrictions from March to mid-July 2020, the German population was advi...
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Article
Open AccessAutomated image quality assessment for selecting among multiple magnetic resonance image acquisitions in the German National Cohort study
In magnetic resonance imaging (MRI), the perception of substandard image quality may prompt repetition of the respective image acquisition protocol. Subsequently selecting the preferred high-quality image data...
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Article
Open AccessA meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health
Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. The placenta is...
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Article
Open AccessFramework and baseline examination of the German National Cohort (NAKO)
The German National Cohort (NAKO) is a multidisciplinary, population-based prospective cohort study that aims to investigate the causes of widespread diseases, identify risk factors and improve early detection...
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Article
Open AccessA comparison of various methods for measuring breast density and breast tissue composition in adolescent girls and women
This study compared different approaches to measuring breast density and breast tissue composition (BTC) in adolescent girls (n = 42, aged 14–16 years) and their mothers (n = 39, aged 36–61 years) from a cohor...
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Article
Open AccessStatistical Analysis in the German National Cohort (NAKO) – Specific Aspects and General Recommendations
The German National Cohort (NAKO) is an ongoing, prospective multicenter cohort study, which started recruitment in 2014 and includes more than 205,000 women and men aged 19–74 years. The study data will be av...
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Article
Open AccessSugar-sweetened beverage consumption and breast composition in a longitudinal study of Chilean girls
Frequent sugar-sweetened beverage (SSB) intake has been associated with indirect markers of breast cancer risk, such as weight gain in adolescents and early menarche. How SSB intake relates to breast compositi...
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Chapter
Considerations in the Design, Conduct, and Interpretation of Studies in Epigenetic Epidemiology
Studies in epigenetic epidemiology may identify epigenetic aberrations associated with disease, link environmental and lifestyle factors to the epigenetic profile, or unveil epigenetic mechanisms underlying st...
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Chapter
The Role of Epigenetics in the Developmental Origins of Health and Disease
The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that the prenatal and early postnatal environments shape the future probability of physical and mental well-being and risk of disease. ...
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Article
Open AccessBenign breast disease and changes in mammographic breast density
Mammographic breast density (MBD) and benign breast disease (BBD) are two of the strongest risk factors for breast cancer. Understanding trends in MBD by age and parity in women with BBD is essential to the cl...
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Article
Open AccessTV viewing during childhood and adult type 2 diabetes mellitus
We examined whether regular television (TV) viewing at ages 3–5 and 5–10 years is related to the incidence of type 2 diabetes mellitus (T2D) in adult women. We used data from 34,512 mother-nurse daughter dyads...
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Article
Open AccessAssociation between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche
Systemic inflammation may play a role in sha** breast composition, one of the strongest risk factors for breast cancer. Pubertal development presents a critical window of breast tissue susceptibility to exog...
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Article
Open AccessGrand-maternal lifestyle during pregnancy and body mass index in adolescence and young adulthood: an intergenerational cohort study
To examine associations of healthy lifestyle during pregnancy with body mass index (BMI) and risk of overweight or obesity of grandchildren during adolescence and young adulthood. Our study population included...
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Article
Open AccessBlutdruckmessung in der NAKO – methodische Unterschiede, Blutdruckverteilung und Bekanntheit der Hypertonie im Vergleich zu anderen bevölkerungsbezogenen Studien in Deutschland
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Article
Open AccessDesign und Qualitätskontrolle der zahnmedizinischen Untersuchung in der NAKO Gesundheitsstudie
Karies und Parodontitis sind weltweit hoch prävalente Erkrankungen. Durch ihre Erfassung im Rahmen der NAKO Gesundheitsstudie können Assoziationen zwischen oralen und systemischen Erkrankungen untersucht werden.
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Article
Open AccessSelbst berichtete Infektionen in der NAKO Gesundheitsstudie – Einordnung in die gegenwärtige Forschungslandschaft
Infektionen spielen für das Krankheitsempfinden, für gesundheitsökonomische Überlegungen sowie Public Health in Deutschland weiterhin eine wichtige Rolle. Sie wurden in den letzten Jahren außerdem mit der Ents...
