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Article
Open AccessA multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% ...
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Vitamin D and Omega-3 Fatty Acid Trial 2017: Addressing Effects on Muscle and Bone
Vitamin D is widely used to benefit skeletal health, but effects on bone are inconsistent. The VITamin D and OmegA-3 TriaL (VITAL) is a large, nationwide randomized controlled trial (RCT) in the USA testing th...
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Article
Open AccessGenome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to d...
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Article
Open AccessGenome-wide association study identifies multiple risk loci for renal cell carcinoma
Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four ...
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Vitamin D and Omega-3 Fatty Acids and Bone Health: Ancillary Studies in the VITAL Randomized Controlled Trial
Vitamin D is widely used to support skeletal health, but results of its effects on bone are inconsistent. The VITamin D and OmegA-3 TriaL (VITAL): Effects on Fractures and Bone Structure and Architecture are 2...
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Article
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
Rachael Stolzenberg-Solomon, Laufey Amundadottir and colleagues report a genome-wide association study of pancreatic cancer. They identify four new susceptibility loci.
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Article
Open AccessGenetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
Gonadotropin releasing hormone (GNRH1) triggers the release of follicle stimulating hormone and luteinizing hormone from the pituitary. Genetic variants in the gene encoding GNRH1 or its receptor may influence...
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Article
Open AccessA prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis
Rheumatoid arthritis (RA) is more common in females than males and sex steroid hormones may in part explain this difference. We conducted a case–control study nested within two prospective studies to determine...
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Article
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
David Hunter and colleagues report results of the CGEMS multistage genome-wide association study of breast cancer. They identify two new risk variants on chromosomes 1p11.2 and 14q24.1, and confirm several pre...
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Article
Open AccessA polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study
Prostaglandins are integral components in the cellular response to inflammation, promoting cellular proliferation and angiogenesis. The enzyme responsible for the conversion of arachidonic acid to prostaglandi...
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Article
Open AccessA comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
Androgens have been hypothesised to influence risk of breast cancer through several possible mechanisms, including their conversion to estradiol or their binding to the oestrogen receptor and/or androgen recep...
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Stop** the Carotene and Retinol Efficacy Trial: The Viewpoint of the Safety and Endpoint Monitoring Committee
We describe our experience with the events that occurred when it began to be suspected that beta-carotene in non-physiological doses had an unexpected adverse effect on the incidence and mortality from lung ca...
