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Open AccessTranscriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin
Epidemiological studies suggest that metformin may reduce the incidence of cancer in patients with diabetes and multiple late phase clinical trials assessing the potential of repurposing this drug are underway...
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Article
Open AccessStudy protocol of a phase II clinical trial of oral metformin for the intravesical treatment of non-muscle invasive bladder cancer
Non-muscle-invasive bladder cancer (NMIBC) is the most common neoplasm of the urinary tract and requires life-long invasive surveillance to detect disease recurrence. Currently, there are no effective oral the...
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Article
A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup
Recent advances indicate that biological aging is a potentially modifiable driver of late-life function and chronic disease and have led to the development of geroscience-guided therapeutic trials such as TAME...
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Article
Menstrual cycle characteristics and steroid hormone, prolactin, and growth factor levels in premenopausal women
Menstrual cycle characteristics are markers of endocrine milieu. However, associations between age at menarche and adulthood sex steroid hormone levels have been inconsistent, and data on menstrual characteris...
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Article
Open AccessCirculating resistin levels and risk of multiple myeloma in three prospective cohorts
Resistin is a polypeptide hormone secreted by adipose tissue. A prior hospital-based case–control study reported serum resistin levels to be inversely associated with risk of multiple myeloma (MM). To date, th...
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Article
Circulating levels of obesity-related markers and risk of renal cell carcinoma in the PLCO cancer screening trial
Obesity is an established risk factor for renal cell carcinoma (RCC). It is unclear what biologic mechanisms underlie this association, although recent evidence suggests that the effects of circulating hormone...
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Article
Cancer, obesity, and diabetes: TKIs exert multiple effects on glucose homeostasis
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Cancer, obesity, diabetes, and antidiabetic drugs: is the fog clearing?
The incidences of obesity, type 2 diabetes mellitus (T2DM), and many cancers are rapidly increasing worldwide; clinicians are increasingly required to treat pa...
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Article
Relapse-free survival of statistically standardized continuous RT-PCR estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2): NCIC CTG MA.14
Recent ASCO/CAP guidelines focus on decision making associated with the presence/absence of continuous breast biomarkers. Statistical standardization (SS) is demonstrated as a method to evaluate the effects of co...
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Article
Octreotide LAR and tamoxifen versus tamoxifen in phase III randomize early breast cancer trials: NCIC CTG MA.14 and NSABP B-29
NCIC CTG MA.14 and NSABP B-29 trials examined the addition of Octreotide LAR (OCT) to 5 years of tamoxifen (TAM). Gallbladder toxicity led to B-29 discontinuation of OCT, and MA.14 OCT administration shortened...
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Article
Open AccessDifferential effects of metformin on breast cancer proliferation according to markers of insulin resistance and tumor subtype in a randomized presurgical trial
Treatment of diabetics with metformin is associated with decreased breast cancer risk in observational studies, but it remains unclear if this drug has clinical antineoplastic activity. In a recent presurgical...
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Article
Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
Elevated plasma levels of branched chain amino acids detected prior to pancreatic cancer diagnosis may result from whole body tissue breakdown occurring during the early stages of this disease.
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Open AccessDual mode of action of metformin on mitochondrial metabolism
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Article
Association of C-peptide and leptin with prostate cancer incidence in the Health Professionals Follow-up Study
Hyperinsulinemia is hypothesized to influence prostate cancer risk. Thus, we evaluated the association of circulating C-peptide, which is a marker of insulin secretion, and leptin, which is secreted in respons...
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Article
Type 2 diabetes and the risk of mortality among patients with prostate cancer
The aim of this study was to determine whether type 2 diabetes is associated with the incidence of prostate cancer mortality and all-cause mortality.
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Article
Fasting insulin and endogenous hormones in relation to premenopausal breast density (Canada)
Mammographic breast density (BD) is associated with increased risk of breast cancer. This study asks which circulating metabolic and reproductive biomarkers are associated with BD, particularly dense breast ar...
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Article
Open AccessAssessment of osteopontin in early breast cancer: correlative study in a randomised clinical trial
Osteopontin (OPN) is a malignancy-associated glycoprotein that contributes functionally to tumor aggressiveness. In metastatic breast cancer, we previously demonstrated that elevated OPN in primary tumor and b...
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Article
Androgen deprivation therapy and the risk of colorectal cancer in patients with prostate cancer
Androgens are known to play an important protective role on colorectal carcinogenesis, and thus the objective of this study was to determine whether androgen deprivation therapy (ADT) is associated with an inc...
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Article
Racial variation in vitamin D cord blood concentration in white and black male neonates
The aim of this study is to evaluate racial variation in umbilical cord blood concentration of vitamin D and to explore its correlation with markers of the insulin-like growth factor axis (IGFs) and sex steroi...
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Article
Insulin-like growth factor-1, insulin-like growth factor-binding protein-3, growth hormone, and mammographic density in the Nurses’ Health Studies
Higher circulating insulin-like growth factor I (IGF-1) levels have been associated with higher mammographic density among women in some, but not all studies. Also, few studies have examined the association be...
