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Article
Open AccessAssociation of early menarche with breast tumor molecular features and recurrence
Early menarche is an established risk factor for breast cancer but its molecular contribution to tumor biology and prognosis remains unclear.
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Article
Open AccessA genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry
Genome-wide studies of gene–environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~...
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Article
Open AccessProlactin levels and breast cancer risk by tumor expression of prolactin-related markers
Higher circulating prolactin has been associated with increased breast cancer risk. Prolactin binding to the prolactin receptor (PRLR) can activate the transcription factor STAT5, thus, we examined the associa...
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Article
Circulating vitamin D and breast cancer risk: an international pooling project of 17 cohorts
Laboratory and animal research support a protective role for vitamin D in breast carcinogenesis, but epidemiologic studies have been inconclusive. To examine comprehensively the relationship of circulating 25-...
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Article
Open AccessAssociation of body mass index and inflammatory dietary pattern with breast cancer pathologic and genomic immunophenotype in the nurses’ health study
Breast tumor immune infiltration is clearly associated with improved treatment response and outcomes in breast cancer. However, modifiable patient factors associated with breast cancer immune infiltrates are p...
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Article
Open AccessPhthalates and bone mineral density: a systematic review
Exposure to endocrine disruptors, such as phthalates, may impact bone mineral density (BMD) through a variety of mechanisms. Studies of phthalate exposure and BMD in humans are scarce.
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Article
Associations of depression status with plasma levels of candidate lipid and amino acid metabolites: a meta-analysis of individual data from three independent samples of US postmenopausal women
Recent animal and small clinical studies have suggested depression is related to altered lipid and amino acid profiles. However, this has not been examined in a population-based sample, particularly in women. ...
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Article
Open AccessLow dose environmental radon exposure and breast tumor gene expression
The International Agency for Research on Cancer classified radon and its decay-products as Group-1-human-carcinogens, and with the current knowledge they are linked specifically to lung cancer. Biokinetic mode...
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Article
Circulating lipids, mammographic density, and risk of breast cancer in the Nurses’ Health Study and Nurses’ Health Study II
Epidemiologic evidence supports an association between high mammographic density and increased breast cancer risk yet etiologic mechanisms remain largely unknown. Mixed evidence exists as to whether circulatin...
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Article
Posttraumatic stress disorder and development of premenstrual syndrome in a longitudinal cohort of women
We examined the association between posttraumatic stress disorder (+PTSD) symptoms and incident premenstrual syndrome (PMS) in a longitudinal study with 14 years follow-up of 2924 women aged 27–44. Compared to...
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Article
Plasma B-vitamins and one-carbon metabolites and the risk of breast cancer in younger women
We examined the association of plasma B-vitamins and metabolites, and related genetic variants, with risk of breast cancer among predominantly premenopausal women.
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Article
The Mind–Body Study: study design and reproducibility and interrelationships of psychosocial factors in the Nurses’ Health Study II
Associations between psychosocial factors and biomarkers are increasingly investigated in studies of cancer incidence and mortality. Documenting optimal data/biospecimen collection protocols and scale properti...
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Article
Pre-diagnostic sex hormone levels and survival among breast cancer patients
Higher levels of circulating sex steroid hormones are associated with increased breast cancer risk, though their association with prognosis remains unclear. We evaluated the association between circulating sex...
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Article
Open AccessBreast cancer risk prediction in women aged 35–50 years: impact of including sex hormone concentrations in the Gail model
Models that accurately predict risk of breast cancer are needed to help younger women make decisions about when to begin screening. Premenopausal concentrations of circulating anti-Müllerian hormone (AMH), a b...
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Article
Open AccessUrinary concentrations of phthalate biomarkers and weight change among postmenopausal women: a prospective cohort study
Some phthalates are endocrine disrupting chemicals used as plasticizers in consumer products, and have been associated with obesity in cross-sectional studies, yet prospective evaluations of weight change are ...
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Article
Open AccessParity, breastfeeding, and breast cancer risk by hormone receptor status and molecular phenotype: results from the Nurses’ Health Studies
Epidemiologic data suggest that parity increases risk of hormone receptor-negative breast cancer and that breastfeeding attenuates this association. Prospective data, particularly on the joint effects of highe...
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Article
Molecular mechanisms linking high body mass index to breast cancer etiology in post-menopausal breast tumor and tumor-adjacent tissues
In post-menopausal women, high body mass index (BMI) is an established breast cancer risk factor and is associated with worse breast cancer prognosis. We assessed the associations between BMI and gene expressi...
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Article
Circulating prolactin concentrations and risk of type 2 diabetes in US women
Prolactin, a multifunctional hormone, is involved in regulating insulin sensitivity and glucose homeostasis in experimental studies. However, whether circulating concentrations of prolactin are associated with...
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Article
Open AccessAndrogen receptor expression in normal breast tissue and subsequent breast cancer risk
Sex steroid hormone signaling is critical in the development of breast cancers, although the role of the androgen receptor remains unclear. This study evaluated androgen receptor (AR) expression in normal brea...
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Article
Carbohydrate and fiber intake and the risk of premenstrual syndrome
Women with premenstrual syndrome (PMS) are encouraged to reduce sugar and increase fiber intake to reduce symptoms. However, research supporting these recommendations is limited, and their role in PMS developm...
