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Chapter and Conference Paper
Early graft failure after heart transplantation: Circulatory assist versus retransplantation
Early graft failure requiring mechanical circulatory support occurred in 12 of our first 257 patients following cardiac transplantation. Three patients had biventricular myocardial failure and were supported b...
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Article
Distinct down-regulation of cardiac β1- and β2-adrenoceptors in different human heart diseases
Cardiac β-adrenoceptor density and β1- and β2-subtype distribution were examined in human left ventricular myocardium from transplant donors serving as controls and from patients with mitral valve stenosis, aorti...
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Article
Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations
The present study was performed to compare the effects of the new positive inotropic phosphodiesterase III inhibitors pimobendan, adibendan, and saterinone on the isometric force of contraction in electrically...
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Article
Nifedipine and diltiazem reduce pulmonary edema formation during postischemic reperfusion of the rabbit lung
A protective effect of calcium antagonists in pulmonary preservation for transplantation has been observed recently. This report focuses on the potential use of diltiazem and nifedipine in the early phase of r...
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Article
Effects of saterinone and its enantiomers R(+)-saterinone and S(−)-saterinone on the phosphodiesterase isoenzymes from ventricular tissue of failing human hearts and porcine hearts
Stereoisomers often exhibit differences in their pharmacological activities. Therefore, the phosphodiesterase inhibitory effects of the cardiotonic agent saterinone in form of the racemate were investigated in...
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Chapter
Cell-cell and cell-matrix adhesion molecules in human heart and lung transplants
The interaction of immune cells with endothelial and target cells and extracellular matrix in human organ transplants is regulated by a number of receptor-ligand molecules. The molecules mediating intercellula...
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Article
Cell-cell and cell-matrix adhesion molecules in human heart and lung transplants
The interaction of immune cells with endothelial and target cells and extracellular matrix in human organ transplants is regulated by a number of receptor-ligand molecules. The molecules mediating intercellula...
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Chapter
Principles of heart allocation
Cardiac transplantation has emerged as an accepted mode of therapy for end stage heart failure. Patients whose life expectancy would otherwise be measured in weeks or months can be offered a form of surgical i...
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Article
Treatment with monoclonal antibodies to ICAM-1 and LFA-1 in rat heart allograft rejection
During allograft rejection, leukocyte infiltration in the graft is regulated by various adhesion molecules. Treatment with monoclonal antibodies to ICAM-1 and LFA-1 (CD11 a) induces specific tolerance after m...
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Article
Detection of diastolic dysfunction: acoustic quantification (AQ) in comparison to Doppler echocardiography
Objectives. To evaluate the potential of acoustic quantification (AQ) in detection of diastolic dysfunction in comparison to Doppler analysis, we investigated, as a model of restrictive filling pattern, nonrej...
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Article
Ultrastructural pathology of the alveolar type II pneumocytes of human donor lungs
Alveolar type II pneumocytes (PII) were studied in 12 human donor lungs perfused with modified Euro-Collins solution during single-lung transplantation (SLTx). While one lung was transplanted, the contralater...
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Article
Porcine endogenous retrovirus (PERV) was not transmitted from transplanted porcine endothelial cells to baboons in vivo
The discussion about the clinical risk of zoonoses in xenotransplantation has recently culminated in the demand for a moratorium on clinical organ transplantation using pig donors. The basis for this discussi...
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Article
Eosinophilic alveolitis in BAL after lung transplantation
Lung transplantation has become a therapeutic option for patients with end stage lung disease. However, outcome after transplantation is complicated by episodes of rejection and infections. Bronchoalveolar la...
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Article
Attitude of patients toward transplantation of xenogeneic organs
Background: The prospect of xenotransplantation has stimulated considerable hopes as well as major concerns. The question of whether or not patients accept xenografts is influenced not only by scientific facts b...
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Article
Simultaneous treatment of thoracic and infrarenal aortic aneurysm using a combination of conventional surgery and endoluminal stent grafting
Introduction: Patients with multiple aortic aneurysms represent a small subgroup with the need for extensive surgical treatment at considerable risk. Endovascular treatment in combination with conventional oper...
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Chapter
Engineering of a miniature 3-D hepatic cell plate culture model
The development of primary liver cell culture techniques has a long standing history that has contributed significantly to our current knowledge about the relevance of individual aspects of the hepatic microen...
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Article
Diazepam metabolism and albumin secretion of porcine hepatocytes in collagen-sandwich after cryopreservation
Cryopreserved porcine hepatocytes in collagen cultures secreted albumin (up to 98 ± 3 μg ml−1; non-cryopreserved controls: 100 ± 9 μg ml−1) and metabolised diazepam (67.5% ± 7.5% of initially applied diazepam are...
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Article
Heart and Heart-Lung Transplantation: Standards and Improvements
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Article
Aktuelles bei der Lungentransplantation Patienten, Indikationen, Techniken und Ergebnisse
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Article
Antikoagulation bei schwangeren Frauen nach künstlichem Herzklappenersatz: Ist niedermolekulares Heparin eine Alternative?
We report on the case of a 24-year-old pregnant woman with acute mechanical mitral valve thrombosis due to a treatment failure of low molecular weight heparin (LMWH) for permanent anticoagulation following me...
