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Article
Open AccessIn a rat model of bypass DuraGraft ameliorates endothelial dysfunction of arterial grafts
Coronary artery bypass surgery can result in endothelial dysfunction due to ischemia/reperfusion (IR) injury. Previous studies have demonstrated that DuraGraft helps maintain endothelial integrity of saphenous...
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Article
Open AccessAn ex-vivo and in-vitro dynamic simulator for surgical and transcatheter mitral valve interventions
Minimally invasive mitral valve surgery (MIMVS) and transcatheter edge-to-edge repair (TEER) are complex procedures used to treat mitral valve (MV) pathologies, but with limited training opportunities availabl...
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Article
Open AccessAcute antiarrhythmic effects of SGLT2 inhibitors–dapagliflozin lowers the excitability of atrial cardiomyocytes
In recent years, SGLT2 inhibitors have become an integral part of heart failure therapy, and several mechanisms contributing to cardiorenal protection have been identified. In this study, we place special emph...
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Article
Open AccessPharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats
Heart transplantation (HTX) is the standard treatment for end-stage heart failure. However, reperfusion following an ischemic period can contribute to myocardial injury. Neutrophil infiltration, along with the...
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Article
Open AccessPressure overload-induced systolic heart failure is associated with characteristic myocardial microRNA expression signature and post-transcriptional gene regulation in male rats
Although systolic function characteristically shows gradual impairment in pressure overload (PO)-evoked left ventricular (LV) hypertrophy (LVH), rapid progression to congestive heart failure (HF) occurs in dis...
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Article
Open AccessComparative evaluation of three commercially available markerless depth sensors for close-range use in surgical simulation
Minimally invasive surgeries have restricted surgical ports, demanding a high skill level from the surgeon. Surgical simulation potentially reduces this steep learning curve and additionally provides quantitat...
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Chapter and Conference Paper
Comparison of Depth Estimation Setups from Stereo Endoscopy and Optical Tracking for Point Measurements
To support minimally-invasive intraoperative mitral valve repair, quantitative measurements from the valve can be obtained using an infra-red tracked stylus. It is desirable to view such manually measured poin...
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Article
Open AccessRenal Safety of Hydroxyethyl starch 130/0.42 After Cardiac Surgery: A Retrospective Cohort Analysis
The risk for renal complications from hydroxyethyl starch 130/0.42 (HES) impacts treatment decisions in patients after cardiac surgery.
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Article
Open AccessPoint detection through multi-instance deep heatmap regression for sutures in endoscopy
Mitral valve repair is a complex minimally invasive surgery of the heart valve. In this context, suture detection from endoscopic images is a highly relevant task that provides quantitative information to anal...
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Article
Open AccessRisk of venous occlusion after lead laser extraction preventing future lead implantation
Lead laser extraction is a well-established method for removing unwanted leads with low morbidity and mortality.
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Article
Open AccessLeft-ventricular hypertrophy in 18-month-old donor rat hearts was not associated with graft dysfunction in the early phase of reperfusion after cardiac transplantation–gene expression profiling
The use of hearts with left-ventricular (LV) hypertrophy (LVH) could offer an opportunity to extend the donor pool for cardiac transplantation. We assessed the effects of LVH in 18-month-old spontaneously hype...
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Article
Hypotherme Perfusion von Spenderherzen mit einer mesenchymale Stammzellen enthaltenden Konservierungslösung
Goldstandard bei terminaler Herzinsuffizienz bleibt die Herztransplantation. Der massive Mangel an Spenderherzen zwingt Transplantationszentren, ältere Spender und längere Ischämiezeiten zu akzeptieren. Die Be...
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Article
Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes
Atrial fibrillation (AF) is associated with electrical remodeling, leading to cellular electrophysiological dysfunction and arrhythmia perpetuation. Emerging evidence suggests a key role for epigenetic mechani...
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Article
Open AccessMesenchymal stem cell-derived conditioned medium protects vascular grafts of brain-dead rats against in vitro ischemia/reperfusion injury
Brain death (BD) has been suggested to induce coronary endothelial dysfunction. Ischemia/reperfusion (IR) injury during heart transplantation may lead to further damage of the endothelium. Previous studies hav...
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Chapter and Conference Paper
Heatmap-based 2D Landmark Detection with a Varying Number of Landmarks
Mitral valve repair is a surgery to restore the function of the mitral valve. To achieve this, a prosthetic ring is sewed onto the mitral annulus. Analyzing the sutures, which are punctured through the annulus...
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Article
Gender and coronary artery bypass grafting in cardiogenic shock
Bypass surgery in patients undergoing cardiogenic shock caused by acute coronary syndrome is one of the most urgent and often performed cardiac operations. It remains unclear if patients gender independently i...
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Article
Open AccessMitral valve flattening and parameter map** for patient-specific valve diagnosis
Intensive planning and analysis from echocardiography are a crucial step before reconstructive surgeries are applied to malfunctioning mitral valves. Volume visualizations of echocardiographic data are often u...
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Chapter and Conference Paper
Abstract: Generative Adversarial Networks for Stereoscopic Hyperrealism in Surgical Training
Phantoms for surgical training are able to mimic cutting and suturing properties and patient-individual shape of organs, but lack a realistic visual appearance that captures the heterogeneity of surgical scene...
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Article
Open AccessExtensive aortic surgery in acute aortic dissection type A on outcome – insights from 25 years single center experience
This single center study compares the different surgical techniques used in the treatment of acute aortic dissection type A (AADA) analyzing the influence of the extent of the surgical approach on outcome.
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Article
Open AccessThe reimplantation valve-sparing aortic root replacement technique for patients with Marfan syndrome: A single-center experience
Valve-sparing aortic root replacement (VSARR) through reimplantation technique is widely regarded as optimal surgical approach for Marfan syndrome (MFS) patients. Perioperative and long-term data from all MFS ...
