Regenerative Medicine - from Protocol to Patient
4. Regenerative Therapies I
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Open AccessCCR2 macrophage response determines the functional outcome following cardiomyocyte transplantation
The immune response is a crucial factor for mediating the benefit of cardiac cell therapies. Our previous research showed that cardiomyocyte transplantation alters the cardiac immune response and, when combine...
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Open AccessExpedient assessment of post-infarct remodeling by native cardiac magnetic resonance imaging in mice
Novel therapeutic strategies aiming at improving the healing process after an acute myocardial infarction are currently under intense investigation. The mouse model plays a central role for deciphering the und...
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Therapeutic potential of menstrual blood-derived endometrial stem cells in cardiac diseases
Despite significant developments in medical and surgical strategies, cardiac diseases remain the leading causes of morbidity and mortality worldwide. Numerous studies involving preclinical and clinical trials ...
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Open AccessMechanisms of stem cell based cardiac repair-gap junctional signaling promotes the cardiac lineage specification of mesenchymal stem cells
Different subtypes of bone marrow-derived stem cells are characterized by varying functionality and activity after transplantation into the infarcted heart. Improvement of stem cell therapeutics requires deep ...
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Open AccessClinical outcomes of conventional surgery versus MitraClip® therapy for moderate to severe symptomatic mitral valve regurgitation in the elderly population: an institutional experience
The aim of this study was to compare treatment of moderate to severe symptomatic mitral regurgitation (MR) with either conventional surgery or the mitral valve edge-to-edge device (MitraClip®) in very elderly ...
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Open AccessGMP-conformant on-site manufacturing of a CD133+ stem cell product for cardiovascular regeneration
CD133+ stem cells represent a promising subpopulation for innovative cell-based therapies in cardiovascular regeneration. Several clinical trials have shown remarkable beneficial effects following their intramyoc...
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Open AccessTRAPLINE: a standardized and automated pipeline for RNA sequencing data analysis, evaluation and annotation
Technical advances in Next Generation Sequencing (NGS) provide a means to acquire deeper insights into cellular functions. The lack of standardized and automated methodologies poses a challenge for the analysi...
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Regenerative Medicine - from Protocol to Patient
3. Tissue Engineering, Biomaterials and Nanotechnology
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Heart
Coronary heart disease and chronic heart failure are common and have an increasing incidence and morbidity in the Western Society. Although revascularization procedures and conventional drug therapy may delay ...
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124I-PET Assessment of Human Sodium Iodide Symporter Reporter Gene Activity for Highly Sensitive In Vivo Monitoring of Teratoma Formation in Mice
Pluripotent stem cell (PSC)-based therapies possess great potential to restore the function of irreversibly damaged organs. PSCs can be differentiated in vitro into any cell type. However, pluripotent potential b...
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Open AccessStreptococcus bovis infectious endocarditis and occult gastrointestinal neoplasia: experience with 25 consecutive patients treated surgically
To assess the prevalence of gastrointestinal neoplasia in patients with Streptococcus bovis infectious endocarditis we performed a retrospective cohort analysis of all episodes of S. bovis infectious endocarditis...
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Open AccessArthralgia and blood culture-negative endocarditis in middle Age Men suggest tropheryma whipplei infection: report of two cases and review of the literature
Whipple’s disease is a rare, often multisystemic chronic infectious disease caused by the rod-shaped bacterium Tropheryma whipplei. Very rarely the heart is involved in the process of the disease, leading to cult...
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The road from systems biology to systems medicine
As research institutions prepare roadmaps for “systems medicine,” we ask how this differs from applications of systems biology approaches in medicine and what we (should) have learned from about one decade of ...
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CD133-Positive Cells for Cardiac Stem Cell Therapy: Current Status and Outlook
Ischemic heart disease represents one major cause of death in developed countries. Ten years ago, cardiac application of bone marrow-derived progenitor cells was introduced as a new therapeutic strategy with t...
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Open AccessValidating intramyocardial bone marrow stem cell therapy in combination with coronary artery bypass grafting, the PERFECT Phase III randomized multicenter trial: study protocol for a randomized controlled trial
For the last decade continuous efforts have been made to translate regenerative cell therapy protocols in the cardiovascular field from ‘bench to bedside’. Successful clinical introduction, supporting safety, ...
