-
Article
Open AccessA stable, engineered TL1A ligand co-stimulates T cells via specific binding to DR3
TL1A (TNFSF15) is a TNF superfamily ligand which can bind the TNFRSF member death receptor 3 (DR3) on T cells and the soluble decoy receptor DcR3. Engagement of DR3 on CD4+ or CD8+ effector T cells by TL1A ind...
-
Article
Open AccessHigh-Throughput Generation of Bipod (Fab × scFv) Bispecific Antibodies Exploits Differential Chain Expression and Affinity Capture
Generation of bispecific antibodies (BsAbs) having two unique Fab domains requires heterodimerization of the two heavy chains and pairing of each heavy chain with its cognate light chain. An alternative bispec...
-
Article
Open AccessRapid Purification of Human Bispecific Antibodies via Selective Modulation of Protein A Binding
Methods to rapidly generate high quality bispecific antibodies (BsAb) having normal half-lives are critical for therapeutic programs. Here, we identify 3 mutations (T307P, L309Q, and Q311R or “TLQ”) in the Fc ...
-
Article
Erratum: Cap** protein regulators fine-tune actin assembly dynamics
Nature Reviews Molecular Cell Biology 15, 677–689 (2014) On page 684 of the above article, there was a mistake in Figure 3b: the PH domain of CARMIL preferentially binds to monophosphorylated membrane lipids r...
