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Article
Modulators of the Nrf2 Signaling Pathway Enhance the Cytotoxic Effect of Standard Chemotherapeutic Drugs on Organoids of Metastatic Colorectal Cancer
The activity of known modulators of the Nrf2 signaling pathway (bardoxolone and brusatol) was studied on cultures of tumor organoids of metastatic colorectal cancer previously obtained from three patients. The...
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Article
Metabolic Reprogramming of Trophoblast Cells in Response to Hypoxia
Hypoxia of trophoblast cells is an important regulator of normal development of the placenta. However, some pathological states associated with hypoxia, e.g. preeclampsia, impair the functions of placental cells....
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Article
Oxyquinoline-Dependent Changes in Claudin-Encoding Genes Contribute to Impairment of the Barrier Function of the Trophoblast Monolayer
Natural response to hypoxia critically depends on rapid stabilization of hypoxia-inducible factor (HIF). Under normoxic conditions, HIF-prolyl hydroxylases mark α-subunits of HIF for degradation, while hypoxia...
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Article
The effect of laminins on chemoresistance of colorectal cancer cells
Earlier, the data on the ability of laminin-332 to protect liver cancer cells from apoptosis caused by doxorubicin, sorafenib, and gefitinib have been obtained. In order to answer the question whether this act...
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Article
Open AccessInterference in transcription of overexpressed genes by promoter-proximal downstream sequences
Despite a high sequence homology among four human RNAi-effectors Argonaute proteins and their coding sequences, the efficiency of ectopic overexpression of AGO3 and AGO4 coding sequences in human cells is grea...
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Article
mRNA expression profile of mouse oligodendrocytes in inflammatory conditions
In this study, we performed transcriptome profiling of oligodendrocyte culture of mice treated with the remyelinating therapeutic agent benztropine in the presence and absence of interferon gamma (IFNγ). The r...
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Article
Open AccessHighly informative marker sets consisting of genes with low individual degree of differential expression
Genes with significant differential expression are traditionally used to reveal the genetic background underlying phenotypic differences between cancer cells. We hypothesized that informative marker sets can b...
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Article
Circulating microRNAs
The detection of miRNAs in plasma and other body fluids opened up a fascinating possibility that animal noncoding RNAs can act as extracellular signaling molecules. In this review, we discuss recent progress i...
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Article
Serum Metabolic Profiles of Pregnant Women with Burdened Obstetrical History
The content of low-molecular-weight components in blood serum was studied by tandem mass-spectrometry in pregnant women. Serum metabolic profiles of patients with a grave obstetrical history were detected. The...
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Article
New functions of small nucleolar RNAs
Small nucleolar RNAs (snoRNAs) are one of the most abundant and well-studied groups of non-coding RNAs. snoRNAs are mostly engaged in processing of rRNA. However, recent data indicate that snoRNAs are also inv...
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Article
Genes potentially associated with Cisplatin resistance of lung cancer cells
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Article
Genes potentially associated with resistance of lung cancer cells to paclitaxel
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Article
Changes in Parameters of Laser-Induced Potentials After Transcutaneous Electroneurostimulation
Changes in nerve conduction after 10-min electroneurostimulation of the posterior surface of the neck were studied. Changes in the parameters of laser-induced potentials obtained during stimulation of C7 derma...
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Article
Association of SLC6A4 Gene 5-HTTLPR Polymorphism with Parameters of Simple and Complex Reaction Times and Critical Flicker Frequency Threshold in Athletes during Exhaustive Exercise
The incidence of SLC6A4 gene 5HTTLPR polymorphism alleles was evaluated in 223 male athletes engaged in endurance sports, the results were compared with those in 177 male nonathletes. Association between 5-HTTLPR...
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Article
Exogenous proteins in exhaled human breath condensate
In the course of analysis of protein composition of exhaled breath to diagnose diseases of the respiratory system the problem is raised to distinguish between proteins, expressed in lung tissues and in respira...
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Article
Relationship between Lactate Concentrations in Active Muscle Sweat and Whole Blood
Lactate (lactic acid) concentrations in sweat and venous and capillary blood of athletes were measured before and after exercise of the maximum aerobic power. Correlations between the increment of blood and sw...
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Article
Modulation of α-Rhythm and Autonomic Status of Human by Color Photostimulation
The effects of photostimulation with different colors on α-rhythm amplitude and parameters of variation pulsometry were studied. Green color stimulation modulates human functions: α-rhythm amplitude increases ...
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Article
Short Highly Intense Exercise Causes Changes in Salivary Concentrations of Hydrocortisone and Secretory IgA
The dynamics of salivary hydrocortisone during exercise depends on the professional status of the athlete. Hydrocortisone concentrations increase and those of secretory IgA decrease significantly during short-...
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Article
Effects of Genetic Variations in the Dopaminergic System on Fatigue in Humans: Gender Aspects
Changes in the functional status under the effect of intense mental exercise were studied in carriers of different variants of DAT1, DRD2, and COMT genes. The volunteers (n=140) performed 3-h monotonous mental wo...
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Article
New Aspects of the Influence of Quadriceps Femoris Muscle Stimulation Course on Functional Capabilities of the Organism
We studied the effect of a course of electrical stimulation of the quadriceps femoris muscle with submaximal contraction under biofeedback conditions on functional capabilities of the organism. In addition to ...
