68 Result(s)
within
**ao-Yu Lu
Science, Humanities and Social Sciences, multidisciplinary
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Article
Experimental validation of inter-subspecific genetic diversity in rice represented by the differences between the DNA sequences of ‘Nipponbare’ and ‘93-11’
The pedigrees of three sequenced rice cultivars were analyzed to show that a majority of the genetic composition of ‘Nipponbare’ originates from japonica cultivars while the minority originates from indica cultiv...
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Open AccessAnalysis on genetic diversification and heterosis in autotetraploid rice
Polyploidization has played an important role in plant evolution and is a pathway for plants to increase genetic diversification and to get higher heterosis comparing with that of diploid does. This study was ...
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Article
Open AccessControl of cotton fibre elongation by a homeodomain transcription factor GhHOX3
Cotton fibres are unusually long, single-celled epidermal seed trichomes and a model for plant cell growth, but little is known about the regulation of fibre cell elongation. Here we report that a homeodomain-...
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Open AccessCharacterization of a Novel Reassortant Influenza A Virus (H2N2) from a Domestic Duck in Eastern China
While H2N2 viruses have been sporadically isolated from wild and domestic birds, H2N2 viruses have not been detected among human populations since 1968. Should H2N2 viruses adapt to domestic poultry they may p...
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Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations
Age-related macular degeneration (AMD) is a leading cause of irreversible central blindness among the elderly worldwide. We use exome sequencing to analyse nonsynonymous single-nucleotide variants (SNVs) acros...
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Open AccessGenetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone
The genome sequences of 175 Ebola virus from five districts in Sierra Leone, collected during September–November 2014, show that the rate of virus evolution seems to be similar to that observed during previous...
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Open AccessGenetic variants of the autophagy pathway as prognostic indicators for prostate cancer
Autophagy is a complex process of autodigestion in conditions of cellular stress and it might play an important role in the pathophysiology during carcinogenesis. We hypothesize that genetic variants of the au...
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Open AccessGossypium barbadense genome sequence provides insight into the evolution of extra-long staple fiber and specialized metabolites
Of the two cultivated species of allopolyploid cotton, Gossypium barbadense produces extra-long fibers for the production of superior textiles. We sequenced its genome (AD)2 and performed a comparative analysis. ...
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Erratum: Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone
Nature 524, 93–96 (2015); doi:10.1038/nature14490 This Letter should have contained an associated Creative Commons statement in the Author Information section. In addition, the Fig. 3c legend should have state...
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Open AccessActivation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection
AMPK is a serine/threonine protein kinase that acts as a positive regulator of autophagy, by phosphorylating ULK1 at specific sites. A previous study demonstrated activation of the macroautophagic system in sc...
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Open AccessA deleterious role for Th9/IL-9 in hepatic fibrogenesis
T helper 9 (Th9) cells, a recently recognized Th cell subset, are involved in autoimmune diseases. We aimed to investigate the role of Th9/interleukin-9 (IL-9) in the pathogenesis of hepatic fibrosis. Th9 and ...
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Open AccessThe distinct clinical features and prognosis of the CD10+MUM1+ and CD10−Bcl6−MUM1− diffuse large B-cell lymphoma
Using an immunohistochemistry (IHC) based method, diffuse large B-cell lymphoma (DLBCL) can be classified into germinal center B-cell (GCB) and non-GCB subtypes. However, the prognostic value of Hans algorithm...
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Open AccessGenetic variants in ultraconserved regions associate with prostate cancer recurrence and survival
Ultraconserved regions (UCRs) are DNA segments of longer than 200 bp in length that are completely conserved between human, rat, and mouse genomes. Recent studies have shown that UCRs are frequently located at...
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Article
Open AccessA novel hepatovirus identified in wild woodchuck Marmota himalayana
Hepatitis A virus (HAV) is a hepatotropic picornavirus that causes acute liver disease worldwide. Here, we report on the identification of a novel hepatovirus tentatively named Marmota Himalayana hepatovirus (MHH...
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Open AccessNon-invasive screening for early Alzheimer’s disease diagnosis by a sensitively immunomagnetic biosensor
Amyloid-beta peptide 1–42 (Aβ42) is considered as a reliable biomarker for the early diagnosis of Alzheimer’s disease (AD). Thus, it is urgent to develop a simple and efficient method for the detection of Aβ42...
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Open AccessInduction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells
Licochalcone A (LCA), a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch, presents obvious anti-cancer effects. In this study, the anti-cancer effects and potential mechanisms...
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Open AccessInvestigation of an unrecognized large-scale outbreak of Candida parapsilosis sensu stricto fungaemia in a tertiary-care hospital in China
A data analysis of yeast collections from the National China Hospital Invasive Fungal Surveillance Net (CHIF-NET) programme in 2013 revealed a sudden increase in the proportion of Candida parapsilosis complex iso...
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Open AccessA newly discovered member of the Atlastin family, BmAtlastin-n, has an antiviral effect against BmNPV in Bombyx mori
Atlastin is a member of the dynamin protein superfamily and it can mediate homotypic fusion of endoplasmic reticulum (ER) membranes, which is required for many biological processes. In this study, a new Atlast...
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Open AccessPdCo/Pd-Hexacyanocobaltate Hybrid Nanoflowers: Cyanogel-Bridged One-Pot Synthesis and Their Enhanced Catalytic Performance
Elaborate architectural manipulation of nanohybrids with multi-components into controllable 3D hierarchical structures is of great significance for both fundamental scientific interest and realization of vario...
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Open AccessMicrowave ablation of hepatocellular carcinoma as first-line treatment: long term outcomes and prognostic factors in 221 patients
This retrospective study aimed at evaluating the long-term outcomes and prognostic factors of microwave ablation (MWA) as a first-line treatment for hepatocellular carcinoma (HCC). 221 consecutive patients rec...
