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Article
Whole Cell-mediated Biocatalytic Synthesis of Helicid Cinnamylate and Its Biological Evaluation as a Novel Tyrosinase Inhibitor
Tyrosinase inhibitors are clinically effective for treating some dermatological disorders related to melanin hyperpigmentation. Accordingly, the discovery and development of tyrosinase inhibitors have great va...
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Article
Mechanism of contractile dysfunction induced by serotonin in coronary artery in spontaneously hypertensive rats
Hypertension is one of the risk factors for coronary heart disease. The present study investigated the mechanism of contractile dysfunction induced by serotonin (5-HT) in coronary artery in spontaneously hyper...
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Article
Catalytic Performance of a Robust Whole-Cell Biocatalyst in the Regioselective Synthesis of Helicid Esters Under Optimized Processing Conditions
In this study, lyophilized Pseudomonas aeruginosa based whole-cell biocatalyst was used in the highly efficient and regioselective acylation of helicid with fatty acid vinyl esters in organic solvents. P. aerugin...
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Article
MLKL mediates apoptosis via a mutual regulation with PERK/eIF2α pathway in response to reactive oxygen species generation
The pseudokinase mixed lineage kinase domain-like protein (MLKL) is a core effector of necroptosis, and its function in necroptosis is widely studied. However, the function of MLKL in apoptosis remains unclear...
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Article
Open AccessAssociation of lymph node involvement with the prognosis of pathological T1 invasive non-small cell lung cancer
Lymph node involvement could help to predict the prognosis of pathological T1 (pT1, diameters of ≤3 cm) non-small cell lung cancer (NSCLC). This study assessed the clinicopathological factors and associated ly...
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Article
Efficient Regioselective Synthesis of the Crotonyl Polydatin Prodrug by Thermomyces lanuginosus Lipase: a Kinetics Study in Eco-friendly 2-Methyltetrahydrofuran
Bio-based solvents have recently been discussed as sustainable green and promising alternatives to conventional organic media for enzymatic processes. In this paper, highly regioselective synthesis of the 6″-O-cr...
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Article
Open AccessInduction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells
Licochalcone A (LCA), a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch, presents obvious anti-cancer effects. In this study, the anti-cancer effects and potential mechanisms...
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Article
Improved synthesis of phosphatidylserine using bio-based solvents, limonene and p-cymene
The bio-based solvents limonene and p-cymene obtained from citrus waste were innovatively employed as the reaction media for enzymatic synthesis of phosphatidylserine.
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Article
Understanding the Behavior of Thermomyces lanuginosus Lipase in Acylation of Pyrimidine Nucleosides Possessing 2′-Substituent
The effect of 2′-differing substituent groups (such as the H, F, Cl, Br, OCH3) as well as various chain lengths of the acyl substrates (C6, C10, and C14) on the performance of Thermomyces lanuginosus lipase for t...
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Article
Regioselective enzymatic procedure for preparing 3′-O-stearoyl-6-azauridine by using Burkholderia cepacia lipase
Previous studies on the lipase-mediated acylation of 6-azauridine with vinyl stearate in organic solvents revealed that while preparing a potential prodrug, 3′-O-stearoyl-6-azauridine, a lipase from Burkholderia ...
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Article
Regioselectivity-reversal in acylation of 6-azauridine catalyzed by Burkholderia cepacia lipase
3′-O-Stearoylation of 6-azauridine was achieved enzymatically for the first time. Among eight commercially available lipases, that from Burkholderia cepacia displayed a 3′-regioselectivity of 80% towards the acyl...
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Article
Highly Regioselective Synthesis of 3′-O-Acyl-Trifluridines Catalyzed by Pseudomonas cepacia Lipase
3′-O-Acyl-trifluridines were prepared successfully through an enzymatic approach for the first time. Among the ten commercially available lipases tested, Pseudomonas cepacia lipase displayed the highest regiosele...
