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Article
Structural Manipulation of Aminal-crosslinked Polybutadiene for Recyclable and Healable Elastomers
Recently, increasingly growing efforts have been devoted to incorporating dynamic covalent bonds into covalently crosslinked networks to address the persistent trade-offs between chemical crosslinking and mall...
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Article
MLKL mediates apoptosis via a mutual regulation with PERK/eIF2α pathway in response to reactive oxygen species generation
The pseudokinase mixed lineage kinase domain-like protein (MLKL) is a core effector of necroptosis, and its function in necroptosis is widely studied. However, the function of MLKL in apoptosis remains unclear...
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Article
Effects of Binding Energy of Bioinspired Sacrificial Bond on Mechanical Performance of cis-1,4-Polyisoprene with Dual-crosslink
Although bioinspired sacrificial bonds have been demonstrated to be efficient in improving the mechanical properties of polymer materials, the effect of binding energy of a specific dynamic bond on the ultimat...
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Article
Open AccessInduction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells
Licochalcone A (LCA), a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch, presents obvious anti-cancer effects. In this study, the anti-cancer effects and potential mechanisms...
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Article
Platycodin D induces apoptosis and triggers ERK- and JNK-mediated autophagy in human hepatocellular carcinoma BEL-7402 cells
Platycodin D, the main saponin isolated from Chinese herb Platycodonis Radix, exhibits anticancer activities against various cancer cell lines. Here we evaluated its anticancer action against human hepatocellu...
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Article
Open AccessPlatycodin D from Platycodonis Radix enhances the anti-proliferative effects of doxorubicin on breast cancer MCF-7 and MDA-MB-231 cells
It has been demonstrated that platycodin D (PD) exhibits anti-cancer activities. This study aims to investigate the anti-proliferative effects of the combination of PD and doxorubicin (DOX) on human breast can...
