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Article
Population pharmacokinetics of ruxolitinib in children with hemophagocytic lymphohistiocytosis: focus on the drug–drug interactions
The optimal dose regimen of ruxolitinib (RUX) in children with hemophagocytic lymphohistiocytosis (HLH) remains to be determined. The aim was to develop and verify a population pharmacokinetic (PPK) model, and...
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Article
Open AccessEffect of Additional Clostridium butyricum on the Intestinal Flora of Chronic Hepatitis B Patients Treated with Entecavir
To explore the influence of intestinal flora on the occurrence, development and antiviral therapy of chronic hepatitis B (CHB), 16S rDNA amplification sequencing was performed to investigate the intestinal flo...
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Article
Open AccessEffect of Entecavir on the Intestinal Microflora in Patients with Chronic Hepatitis B: A Controlled Cross-Sectional and Longitudinal Real-World Study
This study aimed to analyze the diversity of intestinal flora in patients with chronic hepatitis B (CHB) and investigate the effect of entecavir on the intestinal flora in these patients.
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Article
Low-dose rifaximin prevents complications and improves survival in patients with decompensated liver cirrhosis
Rifaximin has been recommended as a prophylactic drug for hepatic encephalopathy (HE) and spontaneous bacterial peritonitis (SBP). This study aims to explore whether low-dose rifaximin can prevent overall comp...
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Article
The prognostic role of liver stiffness in patients with chronic liver disease: a systematic review and dose–response meta-analysis
Liver stiffness measurement (LSM) by transient elastography (TE) has been assessed for the evaluation of clinically relevant outcomes in patients with chronic liver diseases (CLDs) while with variable results....
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Article
Berberine attenuates ischemia–reperfusion injury through inhibiting HMGB1 release and NF-κB nuclear translocation
Inflammatory damage plays an important role in cerebral ischemic pathogenesis and represents a new target for treatment of stroke. Berberine is a natural medicine with multiple beneficial biological activities...
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Article
Open AccessCSH guidelines for the diagnosis and treatment of drug-induced liver injury
Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese med...
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Article
Open AccessGossypium barbadense genome sequence provides insight into the evolution of extra-long staple fiber and specialized metabolites
Of the two cultivated species of allopolyploid cotton, Gossypium barbadense produces extra-long fibers for the production of superior textiles. We sequenced its genome (AD)2 and performed a comparative analysis. ...
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Article
Isolation and characterization of AaAER, a novel double bond reductase from Artemisia annua
We isolated a 2-alkenal reductase (AaAER) gene from Artemisia annua L. cDNA library through homologous cloning strategy. Enzymatic properties of AaAER, including substrate selectivity, enzyme kinetics, and key fa...
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Article
Open AccessControl of cotton fibre elongation by a homeodomain transcription factor GhHOX3
Cotton fibres are unusually long, single-celled epidermal seed trichomes and a model for plant cell growth, but little is known about the regulation of fibre cell elongation. Here we report that a homeodomain-...
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Article
Open AccessCysteine protease enhances plant-mediated bollworm RNA interference
Oral ingestion of plant-expressed double stranded RNA (dsRNA) triggers target gene suppression in insect. An important step of this process is the transmission of dsRNA from plant to midgut cells. Insect perit...
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Article
Quantitative assessment of the association between XRCC6 C1310G polymorphism and cancer risk
X-ray cross-complementing group 6 (XRCC6) plays an important role in the DNA double-strand breaks repair and the maintenance of genomic integrity. XRCC6 C1310G polymorphism may be involved in the development o...
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Article
Vesicular Glutamate Transporter-3 Contributes to Visceral Hyperalgesia Induced by Trichinella spiralis Infection in Rats
According to a recent study, vesicular glutamate transporter-3 (VGLUT3) contributes to injury-induced mechanical hyperalgesia in mice.
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Article
Electronic image stabilization algorithm based on fixed-lag smooth filtering
An algorithm using fixed-lag smooth filtering to improve the precision of EIS algorithm is presented in this paper. Firstly, gray projection algorithm (GPA) is used to calculate the interframe global motion ve...
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Protocol
G Protein Abnormalities in Schizophrenia
Since Emil Kraepelin coined the term dementia praecox, schizophrenia has been recognized as a group of illnesses of unknown etiology sharing common symptomatology with diverse clinical courses. Family, twin, a...
