13 Result(s)
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**anchun Li
Biomedicine
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Article
Role of APR3 in cancer: apoptosis, autophagy, oxidative stress, and cancer therapy
APR3 (Apoptosis-related protein 3) is a gene that has recently been identified to be associated with apoptosis. The gene is located on human chromosome 2p22.3 and contains both transmembrane and EGF (epidermal gr...
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Article
Open AccessComprehensive analysis identifies CLEC1B as a potential prognostic biomarker in hepatocellular carcinoma
C-type lectin domain family 1 member B (CLEC1B, encoding the CLEC-2 protein), a member of the C-type lectin superfamily, is a type II transmembrane receptor involved in platelet activation, angiogenesis, and i...
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Article
Podocarpusflavone alleviated renal fibrosis in obstructive nephropathy by inhibiting Fyn/Stat3 signaling pathway
Tubulointerstitial fibrosis is a common pathological change in end-stage renal disease. However, limited treatment methods are developed, and unexplained potential mechanisms of renal diseases are urgent probl...
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Article
Open AccessIdentification of mitochondrial respiratory chain signature for predicting prognosis and immunotherapy response in stomach adenocarcinoma
Stomach adenocarcinoma (STAD) is the third leading cause of cancer-related deaths and the fifth most prevalent malignancy worldwide. Mitochondrial respiratory chain complexes play a crucial role in STAD pathog...
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Article
Open AccessCharacterization of pyruvate metabolism and citric acid cycle patterns predicts response to immunotherapeutic and ferroptosis in gastric cancer
Gastric cancer is one of the most common malignancies of the digestive system with a high lethal rate. Studies have shown that inherited and acquired mutations in pyruvate metabolism and citric acid cycle (P-C...
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Article
Phoenixin-20 Ameliorates Lipopolysaccharide-Induced Activation of Microglial NLRP3 Inflammasome
Injury associated with neuroinflammation has been linked with several kinds of neurodegenerative diseases. The activation of the NLRP3 inflammasome plays an important role in microglia-mediated inflammation. P...
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Article
Association Between rs1815739 Polymorphism of ACTN3 Gene and Athletic Ability in Chinese Sprinters
The aim of this study was to investigate the prevalence of the ACTN3 rs1815739 polymorphism and to study its association with athletes’ level of competition and lower-extremity power.
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Article
Piceatannol inhibits phorbol ester-induced expression of COX-2 and iNOS in HR-1 hairless mouse skin by blocking the activation of NF-κB and AP-1
The present study was aimed at elucidating the molecular mechanisms of anti-inflammatory activity of piceatannol (trans-3,4,3′,5′-tetrahydroxystilbene) in mouse skin in vivo.
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Article
Open AccessThe expression profile of Dopamine D2 receptor, MGMT and VEGF in different histological subtypes of pituitary adenomas: a study of 197 cases and indications for the medical therapy
To study the expression of D2R, MGMT and VEGF for clinical significance in pituitary adenomas, and to predict the potential curative medical therapy of dopamine agonists, temozolomide and bevacizumab on pituit...
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Article
Open AccessA heterozygous moth genome provides insights into herbivory and detoxification
Minsheng You and colleagues report the whole-genome sequence of the diamondback moth, Plutella xylostella. Their transcriptome analysis from different life stages, together with comparative genomic and phylogenet...
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Article
Open AccessSilencing IL-23 expression by a small hairpin RNA protects against asthma in mice
To determine the impact of IL-23 knockdown by RNA interference on the development and severity of ovalbumin (OVA)-induced asthmatic inflammation, and the potential mechanisms in mice, the IL-23-specific RNAi-e...
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Chapter
The CXCR3/CXCL3 Axis in Cancer
CXCR3 is a G protein-coupled receptor that binds the chemokines CXCL9 (Mig), CXCL10 (IP-10), and CXCL11 (I-Tac). The murine receptor also binds CCL21. CXCR3 is expressed on activated T cells, B cells, Natural ...
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Chapter and Conference Paper
Modulation of Inspiratory Inhibition of the Bötzinger Complex by Raphe Pallidus and Locus Coeruleus in Rabbits
In mammals, the respiratory rhythm is generated by the brainstem neuronal network. The Bötzinger complex (Böt.C) is a group of inhibitory expiratory neurons at the rostral end of the ventral respiratory group ...
