Skip to main content

14 Result(s)

within Amy M. Fulton Remove this filter

and

  1. Article

    Open Access

    A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis

    Two-pore domain potassium (K2P) channels act to maintain cell resting membrane potential—a prerequisite for many biological processes. KCNK9, a member of K2P family, is implicated in cancer, owing to its overe...

    Han Sun, Liqun Luo, Bachchu Lal, **nrong Ma, Lie** Chen… in Nature Communications (2016)

    Download PDF (1455 KB) View Article

  2. No Access

    Article

    Divergent roles of CXCR3 isoforms in promoting cancer stem-like cell survival and metastasis

    There is growing evidence that several chemokine receptors including CXCR3 contribute to metastasis of breast and other cancers, however, in order to target CXCR3 effectively, it is critical to understand the...

    Yanchun Li, Jocelyn C. Reader, **nrong Ma… in Breast Cancer Research and Treatment (2015)

  3. No Access

    Article

    Frondoside A inhibits breast cancer metastasis and antagonizes prostaglandin E receptors EP4 and EP2

    Frondoside A, derived from the sea cucumber Cucumaria frondosa has demonstrable anticancer activity in several models, however, the ability of Frondoside A to affect tumor metastasis has not been reported. Using ...

    **nrong Ma, Namita Kundu, Peter D. Collin… in Breast Cancer Research and Treatment (2012)

  4. No Access

    Article

    Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function

    Cyclooxygenase-2 (COX-2) is associated with aggressive breast cancers. The COX-2 product prostaglandin E2 (PGE2) acts through four G-protein-coupled receptors designated EP1–4. Malignant and immortalized normal m...

    Namita Kundu, **nrong Ma, Dawn Holt, Olga Goloubeva… in Breast Cancer Research and Treatment (2009)

  5. No Access

    Article

    The chemokine receptors CXCR4 and CXCR3 in cancer

    Chemokines comprise a superfamily of at least 46 cytokines that were initially described based on their ability to bind to 18 to 22 G protein-coupled receptors to induce the directed migration of leukocytes to...

    Amy M. Fulton in Current Oncology Reports (2009)

  6. No Access

    Book

    Chemokine Receptors in Cancer

    Amy M. Fulton in Cancer Drug Discovery and Development (2009)

  7. No Access

    Chapter

    The CXCR3/CXCL3 Axis in Cancer

    CXCR3 is a G protein-coupled receptor that binds the chemokines CXCL9 (Mig), CXCL10 (IP-10), and CXCL11 (I-Tac). The murine receptor also binds CCL21. CXCR3 is expressed on activated T cells, B cells, Natural ...

    Yanchun Li, Amy M. Fulton in Chemokine Receptors in Cancer (2009)

  8. No Access

    Chapter

    Chemokine Receptors in Cancer: Pathobiology and Potential Therapeutic Targets

    Many chemokine receptors have now been detected in a variety of malignancies. Considerable data now exist that two receptors, CXCR4 and CCR7, are widely expressed in epithelial cancers and contribute to the ab...

    Tonya C. Walser, Amy M. Fulton in The Chemokine Receptors (2007)

  9. No Access

    Article

    Cyclooxygenase inhibitors modulate NK activities that control metastatic disease

    Cyclooxygenase (COX) inhibitors have demonstrated efficacy in models of human cancer but the relevant mechanisms have not all been elucidated. Both Cox-dependent as well as Cox-independent mechanisms have been...

    Namita Kundu, Tonya C. Walser, **nrong Ma… in Cancer Immunology, Immunotherapy (2005)

  10. Article

    Promoter methylation regulates cyclooxygenase expression in breast cancer

    Overexpression of cyclooxygenase (COX-2) is commonly observed in human cancers. In a murine model of metastatic breast cancer, we observed that COX-2 expression and enzyme activity were associated with enhanced t...

    **nrong Ma, Qingyuan Yang, Keith T Wilson, Namita Kundu… in Breast Cancer Research (2004)

    Download PDF (604 KB) View Article

  11. No Access

    Article

    Cyclooxygenase Inhibitors Block Cell Growth, Increase Ceramide and Inhibit Cell Cycle

    We have shown previously in a model of metastatic breast cancer that murine mammary tumor cells express both cyclooxygenase-1 (Cox-1) and Cox-2 isoforms. Growth and metastasis of these tumors in syngeneic host...

    Namita Kundu, Miriam J. Smyth, Leigh Samsel… in Breast Cancer Research and Treatment (2002)

  12. No Access

    Article

    Sublethal oxidative stress inhibits tumor cell adhesion and enhances experimental metastasis of murine mammary carcinoma

    We have postulated that murine mammary tumor progression is fueled, in part, by tumor-associated macrophages that deliver sub-lethal oxidative stress to tumor cells. In the present study, we determined whether...

    Namita Kundu, Shaozeng Zhang, Amy M. Fulton in Clinical & Experimental Metastasis (1995)

  13. No Access

    Chapter

    Prostaglandins and Tumor Metastasis

    There is considerable evidence that lipids, and specifically prostaglandins (pgs), can contribute to progressive tumor growth (1). Many studies provide evidence that lipids can contribute to early steps in car...

    Amy M. Fulton in Carcinogenesis and Dietary Fat (1989)

  14. No Access

    Chapter

    Prostaglandins in Breast Cancer

    The prostaglandins (PGs) are a group of lipids synthesized from arachidonic acid via the cyclooxygenase pathway; other cyclooxygenase products, including thromboxane and prostacyclin, as well as lipoxygenase- ...

    Amy M. Fulton in Cellular and Molecular Biology of Mammary Cancer (1987)