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Article
Open AccessSAMHD1-induced endosomal FAK signaling promotes human renal clear cell carcinoma metastasis by activating Rac1-mediated lamellipodia protrusion
Human sterile α motif and HD domain-containing protein 1 (SAMHD1) has deoxyribonucleoside triphosphohydrolase (dNTPase) activity that allows it to defend against human immunodeficiency virus type I (HIV-1) inf...
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Article
Open AccessDynamic roles of inflammasomes in inflammatory tumor microenvironment
The inflammatory tumor microenvironment has been known to be closely connected to all stages of cancer development, including initiation, promotion, and progression. Systemic inflammation in the tumor microenv...
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Article
Isoflavone intake on the risk of overall breast cancer and molecular subtypes in women at high risk for hereditary breast cancer
We investigated the association between isoflavone (ISF) intake and hereditary breast cancer (BC) risk, particularly by molecular subtype, in East-Asian BRCA1/2 mutation carriers and non-carriers at a high risk o...
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Article
Open AccessHelicobacter pylori infection induces STAT3 phosphorylation on Ser727 and autophagy in human gastric epithelial cells and mouse stomach
Helicobacter pylori (H. pylori) infection is considered as one of the principal risk factors of gastric cancer. Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) plays an i...
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Article
Open AccessGremlin-1 augments the oestrogen-related receptor α signalling through EGFR activation: implications for the progression of breast cancer
Gremlin-1 (GREM1), one of the bone morphogenetic protein antagonists, is involved in organogenesis, tissue differentiation and kidney development. However, the role of GREM1 in cancer progression and its under...
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Article
Open Access17β-Estradiol supplementation changes gut microbiota diversity in intact and colorectal cancer-induced ICR male mice
The composition of the gut microbiota is influenced by sex hormones and colorectal cancer (CRC). Previously, we reported that 17β-estradiol (E2) inhibits azoxymethane/dextran sulfate sodium (AOM/DSS)-induced t...
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Modulation of Cancer Cell Growth and Progression by Caveolin-1 in the Tumor Microenvironment
Caveolin-1 (Cav-1), a major structural component of cell membrane , is involved in a variety of intracellular signaling pathways as well as transmembrane transport. Cav-1, as a scaffolding protein, modulates ...
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Article
Metabolic signaling functions of the heme oxygenase/CO system in metabolic diseases
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Article
Open AccessCarbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury
Carbon monoxide (CO) can confer protection against cellular stress, whereas the potential involvement of autophagy and lysosomal biogenesis remains incompletely understood. We demonstrate here that the activat...
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Article
Open AccessCurcumin interacts directly with the Cysteine 259 residue of STAT3 and induces apoptosis in H-Ras transformed human mammary epithelial cells
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is latent but constitutively activated in many types of cancers. It is well known that STAT3 plays a key role in inflam...
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Article
Open AccessHypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9
During the metastatic phase, cancer cells require the dissolution of cadherin-mediated cell-cell adhesion and a dramatic re-organization of the cytoskeleton through epithelial-mesenchymal transition (EMT), the...
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Article
Open AccessEndogenous ω-3 Fatty Acid Production by fat-1 Transgene and Topically Applied Docosahexaenoic Acid Protect against UVB-induced Mouse Skin Carcinogenesis
The present study was intended to explore the effects of endogenously produced ω-3 polyunsaturated fatty acids (PUFAs) on ultraviolet B (UVB)-induced skin inflammation and photocarcinogenesis using hairless fat-1
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Therapeutic Potential and Molecular Targets of Piceatannol in Chronic Diseases
Piceatannol (3,3′,4,5′-tetrahydroxy-trans-stilbene; PIC) is a naturally occurring stilbene present in diverse plant sources. PIC is a hydroxylated analog of resveratrol and produced from resveratrol by microsomal...
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Article
Chemopreventive and Therapeutic Potential of Phytochemicals Targeting Cancer Stem Cells
Cancer stem cells (CSCs) constitute a subpopulation of transformed cells that possess intrinsic ability to undergo self-renewal and differentiation, which confers resistance to conventional anti-cancer therapy...
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Article
Open AccessMagnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathway
Magnolin is a natural compound abundantly found in Magnolia flos, which has been traditionally used in oriental medicine to treat headaches, nasal congestion and anti-inflammatory reactions. Our recent results ha...
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Article
Piceatannol inhibits phorbol ester-induced expression of COX-2 and iNOS in HR-1 hairless mouse skin by blocking the activation of NF-κB and AP-1
The present study was aimed at elucidating the molecular mechanisms of anti-inflammatory activity of piceatannol (trans-3,4,3′,5′-tetrahydroxystilbene) in mouse skin in vivo.
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The Azoxymethane Plus Dextran Sulfate Sodium-Induced Mouse Colon Cancer Model for the Study of Dietary Chemoprevention of Inflammation-Associated Carcinogenesis
The azoxymethane (AOM) plus dextran sulfate sodium (DSS)-induced mouse colon carcinogenesis model is a fascinating tool for investigating the pathogenesis and chemoprevention of colitis-associated colorectal c...
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Article
Resolution of inflammation as a novel chemopreventive strategy
Acute inflammation, a physiologic response to protect cells from microbial infection and other noxious stimuli, is automatically terminated by endogenous anti-inflammatory and pro-resolving mediators to restor...
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Chapter
Cancer Chemopreventive and Therapeutic Potential of Guggulsterone
Guggulsterone (GS) is a phytosterol derived from the gum resin of guggul plants that have been used traditionally to treat various disorders such as burns, wounds, gastric ulcer, cough, gum diseases, urinary c...
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Chapter
Helicobacter pylori-Induced Oxidative Stress and Inflammation
Reactive oxygen species (ROS) are considered to be the important regulator in the pathogenesis of Helicobacter pylori-induced gastric ulceration and carcinogenesis. The sources of ROS are thought to be activated ...
