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Article
Are the effects of prolonged cold ischemia a barrier to long-distance transportation of living donor kidneys?
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Human Leukocyte Antigen Antibodies for Monitoring Transplant Patients
Human leukocyte antigen (HLA) antibody-mediated hyperacute rejection has dramatically decreased since the clinical introduction of crossmatch technology. However, the role of HLA antibody in acute and chronic ...
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Article
Longmire Lecture: My 50 Years at the University of California, Los Angeles
The main concept driving my work has been the humoral theory of immunity to allografts. It led to the development of the microlymphocytotoxicity test, which is used to look for the relevant transplant antigen...
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Historic Landmarks in Clinical Transplantation: Conclusions from the Consensus Conference at the University of California, Los Angeles
The transplantation of organs, cells, and tissues has burgeoned during the last quarter century, with the development of multiple new specialty fields. However, the basic principles that made this possible we...
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Article
Cancer-associated quantitative differences in antigen levels of sialosyl Lewisx in stool from patients with colorectal carcinomas
A microenzyme-linked immunosorbent assay system employing monoclonal antibody SNH3 was developed for the detection of sialosyl Lewisx antigen in stool extracts from 80 patients with colorectal cancer, 13 patients...
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Article
Cytotoxic T cell lines recognize autologous and allogeneic melanomas with shared or cross-reactive HLA-A
Cytotoxic T lymphocytes (CTL), CD3+, α/β T-cell-receptor-positive, are important effector cells with specific immunity in melanoma patients. The establishment and expansion in vitro of CTL of a specific phenotype...
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Article
Immunohistochemical examination of lung cancers using monoclonal antibodies reacting with sialosylated Lewisx and sialosylated Lewisa
In order to explore the relationship between the expression of cancer-associated glycolipids such as sialylated Lex (SLEX) and sialylated Lea (SLEA) and the histological subtypes of lung cancers, 30 cases of smal...
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Article
Antibody responses following rubella immunization analyzed by HLA and ABO types
HLA ty** was performed on 232 rubella seronegative (HAI antibody titer <8) children immunized with RA 27/3 vaccine. High convalescentphase geometric mean antibody titers were noted in children one to five ye...
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Article
ANTIBODIES TO B-LYMPHOCYTES IN RENAL TRANSPLANTATION
Antibodies (ab) in the serum of allograft recipients against donor lymphocytes (L) are associated with graft rejection. Because ab may be produced against B cell (BC) antigens (ag) as well as HLA ag, we prospe...
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Article
Cross-reactivity between human and murine lymphocyte antigens: III. Reactivity of H-2 allo- and xenoantisera with human lymphoid cells
H-2 alloantisera and antimouse lymphocyte xenoantisera react with 14%–100% of human lymphocytes from a panel of at least 80 unrelated people. Population and family studies did not reveal HL-A specificity of su...
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INCREASED INCIDENCE OF W27 IN JUVENILE RHEUMATOID ARTHRITIS
The frequencies of 24 hlstocompatibility antigens (HL-A) were examined in 26 patients with juvenile rheumatoid arthritis (JRA). Specificity W27 was noted in 42 per cent (11 patients) compared to 6 per cent of ...
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Article
Leucocyte Antigens in Man : A Comparison of Lymphocytotoxic and Agglutination Assays for their Detection
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Microdroplet Assay of Human Serum Cytotoxins
ATTEMPTS to define leucocyte groups in man serologically have been hampered by the scarcity of immune human antisera and the capriciousness of the leuco-agglutination reaction1. The method recorded here for assay...