270 Result(s)

Article

Tubular aryl hydratocarbon receptor upregulates EZH2 to promote cellular senescence in cisplatin-induced acute kidney injury

Acute kidney injury (AKI) is one of the serious clinical syndromes with high morbidity and mortality. Despite substantial progress in understanding the mechanism of AKI, no effective drug is available for trea...

Li Wen, Qian Ren, Fan Guo, **aoyan Du, Hongliu Yang, ** Fu… in Cell Death & Disease (2023)

Article

Functional investigation of SLC1A2 variants associated with epilepsy

Epilepsy is a common neurological disorder and glutamate excitotoxicity plays a key role in epileptic pathogenesis. Astrocytic glutamate transporter GLT-1 is responsible for preventing excitotoxicity via clear...

Qi Qu, Wenlong Zhang, Ji Wang, Dongmei Mai, Siqiang Ren… in Cell Death & Disease (2022)

Article

FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM

Doxorubicin (DOX) is an effective anthracycline chemotherapeutic anticancer drug with its life-threatening cardiotoxicity severely limiting its clinical application. Mitochondrial damage-induced cardiomyocyte ...

Yaguang Bi, Haixia Xu, **ang Wang, Hong Zhu, Junbo Ge, Jun Ren… in Cell Death & Disease (2022)

Article

Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish

Mutations in TUB-like protein 1 (TULP1) are associated with severe early-onset retinal degeneration in humans. However, the pathogenesis remains largely unknown. There are two homologous genes of TULP1 in zebrafi...

Danna Jia, Pan Gao, Yuexia Lv, Yuwen Huang, James Reilly, Kui Sun… in Cell Death & Disease (2022)

Article

Muscular Swedish mutant APP-to-Brain axis in the development of Alzheimer’s disease

Alzheimer’s disease (AD) is the most common form of dementia. Notably, patients with AD often suffer from severe sarcopenia. However, their direct link and relationship remain poorly understood. Here, we gener...

**-**u Pan, Daehoon Lee, Dong Sun, Kai Zhao, Lei **ong… in Cell Death & Disease (2022)

Article

Targeted activation of GPER enhances the efficacy of venetoclax by boosting leukemic pyroptosis and CD8+ T cell immune function in acute myeloid leukemia

Acute myeloid leukemia (AML) is a rapidly progressing and often fatal hematopoietic malignancy. Venetoclax (VEN), a recent FDA-approved BCL-2 selective inhibitor, has high initial response rates in elderly AML...

Jun Ren, Yonghong Tao, Meixi Peng, Qiaoling **ao, Yipei **g… in Cell Death & Disease (2022)

Article

Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a prominent extracellular matrix (ECM) deposition and poor prognosis. High levels of ECM proteins derived from tumour cells reduce the efficacy o...

Tianyi Zhang, Yanxian Ren, Pengfei Yang, Jufang Wang, Heng Zhou in Cell Death & Disease (2022)

Article

Correction to: N6-methyladenosine modification of circ_0003215 suppresses the pentose phosphate pathway and malignancy of colorectal cancer through the miR-663b/DLG4/G6PD axis

Baoxiang Chen, Yuntian Hong, Rui Gui, Huabin Zheng, Shunhua Tian… in Cell Death & Disease (2022)

Article

LCAT1 is an oncogenic LncRNA by stabilizing the IGF2BP2-CDC6 axis

Long non-coding RNAs (lncRNAs) is known to play vital roles in modulating tumorigenesis. We previously reported that LCAT1, a novel lncRNA, promotes the growth and metastasis of lung cancer cells both in vitro...

Juze Yang, **nyi Qian, Qiongzi Qiu, Lingling Xu, Meidie Pan, Jia Li… in Cell Death & Disease (2022)

Article

HSF2BP protects against acute liver injury by regulating HSF2/HSP70/MAPK signaling in mice

Heat shock proteins (HSPs) depletion and protein misfolding are important causes of hepatocyte death and liver regeneration disorder in liver injury. HSF2BP, as its name implies, is a binding protein of HSF2, ...

Jianbin Bi, Jia Zhang, Mengyun Ke, Tao Wang, Mengzhou Wang… in Cell Death & Disease (2022)

Article

N6-methyladenosine modification of circ_0003215 suppresses the pentose phosphate pathway and malignancy of colorectal cancer through the miR-663b/DLG4/G6PD axis

Circular RNAs (circRNAs) are a recently discovered kind of regulatory RNAs that have emerged as critical biomarkers of various types of cancers. Metabolic reprogramming has gradually been identified as a disti...

Baoxiang Chen, Yuntian Hong, Rui Gui, Huabin Zheng, Shunhua Tian… in Cell Death & Disease (2022)

Article

Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis

Endometriosis (EM) is one of the vanquished wonted causes of chronic pelvic sting in women and is closely associated with infertility. The long-term, complex, systemic, and post-treatment recurrence of EM wrea...

Chao Lu, Pengyun Qiao, Ruihai Fu, Yadi Wang, Jiayi Lu, ** Ling… in Cell Death & Disease (2022)

Article

KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer

Colorectal cancer (CRC) is the second leading cause of cancer mortality worldwide. However, the molecular mechanisms underlying CRC progression remain to be further defined to improve patient outcomes. In this...

Hanhui Yao, Delong Ren, Yichun Wang, Liang Wu, Yang Wu, Wei Wang… in Cell Death & Disease (2022)

Article

ER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by gradual loss of memory and cognitive function, which constitutes a heavy burden on the healthcare system globally. Current ...

Amir Ajoolabady, Dan Lindholm, Jun Ren, Domenico Pratico in Cell Death & Disease (2022)

Article

shRNA‑mediated knockdown of KNTC1 inhibits non-small-cell lung cancer through regulating PSMB8

In view of the important roles played by Kinetochore proteins in mitosis, we believed that they may contribute to the development and progression of human cancers, which has been reported recently elsewhere. K...

Ruijun Liu, Ruili Liu, Zhiyi Guo, Jianghao Ren, Jia Huang… in Cell Death & Disease (2022)

Article

Regulatory T cells in skeletal muscle repair and regeneration: recent insights

Skeletal muscle repair and regeneration after injury is a multi-stage process, involving a dynamic inflammatory microenvironment consisting of a complex network formed by the interaction of immune cells and th...

Jianhui Wu, Bowen Ren, Daochao Wang, Hui Lin in Cell Death & Disease (2022)

Article

The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages

The discovery of STING-related innate immunity has recently provided a deep mechanistic understanding of immunopathy. While the detrimental effects of STING during sepsis had been well documented, the exact me...

Jie Wu, Qinjie Liu, Xufei Zhang, Miaomiao Tan, Xuanheng Li… in Cell Death & Disease (2022)

Article

Single-cell profiling of immune cells after neoadjuvant pembrolizumab and chemotherapy in IIIA non-small cell lung cancer (NSCLC)

The combination of immune checkpoint inhibitors (ICIs) with chemotherapy (chemoimmunotherapy) in the neoadjuvant setting have achieved favorable clinical benefits in non-small cell lung cancer (NSCLC), but the...

Zhenzhen Hui, Jiali Zhang, Yulin Ren, **aoling Li, Cihui Yan… in Cell Death & Disease (2022)

Article

Novel roles of LSECtin in gastric cancer cell adhesion, migration, invasion, and lymphatic metastasis

Liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin) plays an important regulatory role in a variety of diseases, including tumors. However, the underlying mechanism of LSECtin in gastric c...

Yinan Zhang, Zhen Feng, Yue Xu, Sufen Jiang, Qianshi Zhang… in Cell Death & Disease (2022)

Article

S100A11 activates the pentose phosphate pathway to induce malignant biological behaviour of pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is one of the most refractory malignancies and has a poor prognosis. In recent years, increasing evidence has shown that an imbalance of metabolism may contribute to unr...

Xue Zeng, Hong Guo, Zhuang Liu, Zilan Qin, Yuyang Cong, Naihan Ren… in Cell Death & Disease (2022)