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Article
Open AccessTargeted activation of GPER enhances the efficacy of venetoclax by boosting leukemic pyroptosis and CD8+ T cell immune function in acute myeloid leukemia
Acute myeloid leukemia (AML) is a rapidly progressing and often fatal hematopoietic malignancy. Venetoclax (VEN), a recent FDA-approved BCL-2 selective inhibitor, has high initial response rates in elderly AML...
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Article
Open AccessMutant NPM1-regulated lncRNA HOTAIRM1 promotes leukemia cell autophagy and proliferation by targeting EGR1 and ULK3
Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1), which displays a distinct long noncoding RNA (lncRNA) expression profile, has been defined as a unique subgroup in the new classification of myel...
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Article
A 1-V, 82-dB, 2.5-MS/s, single loop, single bit delta-sigma modulator in 0.13-μm CMOS technology
It is challenging to design high speed Delta-Sigma modulator using sub-micron process with low supply voltage. Compared with multi-stage or multi-bit design, the single loop, single bit Delta-Sigma modulator h...