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Article
Endothelial dysfunction: mechanisms and contribution to diseases
The endothelium, lining the inner surface of blood vessels and spanning approximately 3 m2, serves as the largest organ in the body. Comprised of endothelial cells, the endothelium interacts with other bodily com...
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Article
Open AccessAlzheimer’s disease: using gene/protein network machine learning for molecule discovery in olive oil
Alzheimer’s disease (AD) poses a profound human, social, and economic burden. Previous studies suggest that extra virgin olive oil (EVOO) may be helpful in preventing cognitive decline. Here, we present a netw...
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Retraction Note to: Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy
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Article
Retraction Note: VPS35 regulates tau phosphorylation and neuropathology in tauopathy
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Article
QTC-4-MeOBnE Ameliorated Depressive-Like Behavior and Memory Impairment in 3xTg Mice
Growing evidence has associated major depressive disorder (MDD) as a risk factor or prodromal syndrome for the occurrence of Alzheimer’s disease (AD). Although this dilemma remains open, it is widely shown th...
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Article
Retraction Note to: Full recovery of the Alzheimer’s disease phenotype by gain of function of vacuolar protein sorting 35
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Ferroptosis: A Promising Therapeutic Target for Cardiovascular Diseases
Cardiovascular diseases (CVDs) refer to a group of conditions that affect the heart and blood vessels and are a leading cause of death worldwide. Ferroptosis is an iron-dependent regulated cell death process t...
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Article
The Alzheimer’s disease GWAS risk alleles in the ABCA7 promoter and 5’ region reduce ABCA7 expression
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Open AccessER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by gradual loss of memory and cognitive function, which constitutes a heavy burden on the healthcare system globally. Current ...
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Article
1-(7-Chloroquinolin-4-yl)-N-(4-Methoxybenzyl)-5-Methyl-1H-1,2, 3-Triazole-4- carboxamide Reduces Aβ Formation and Tau Phosphorylation in Cellular Models of Alzheimer’s Disease
1-(7-Chloroquinolin-4-yl)-N-(4-methoxybenzyl)-5-methyl-1H-1,2,3-triazole-4- carboxamide (QTC-4-MeOBnE) is a new multi-target directed ligand (MTDL) rationally designed to have affinity with β-secretase (BACE), Gl...
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Article
Regional and temporal miRNAs expression profile in a transgenic mouse model of tauopathy: implication for its pathogenesis
Studies have shown that the expression level of different microRNAs (miRNAs) is altered in neurodegenerative disorders including tauopathies, a group of diseases pathologically defined by accumulation of tau p...
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RETRACTED ARTICLE: VPS35 regulates tau phosphorylation and neuropathology in tauopathy
The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking. Deficiency in VPS35 by altering APP/Aβ metab...
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Article
Gestational high fat diet protects 3xTg offspring from memory impairments, synaptic dysfunction, and brain pathology
Maternal history for sporadic Alzheimer’s disease (AD) predisposes the offspring to the disease later in life. However, the mechanisms behind this phenomenon are still unknown. Lifestyle and nutrition can dire...
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Open AccessCorrection to: A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles
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Downregulation of autophagy by 12/15Lipoxygenase worsens the phenotype of an Alzheimer’s disease mouse model with plaques, tangles, and memory impairments
Among the different initiating events in Alzheimer’s disease (AD) pathogenesis, oxidative stress and neuroinflammation are some of the most iimportant. In the central nervous system, the 12/15Lipoxygenase (12/...
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Article
RETRACTED ARTICLE: Full recovery of the Alzheimer’s disease phenotype by gain of function of vacuolar protein sorting 35
Deficit in retromer complex function secondary to lower levels of one of its major components, the vacuolar protein sorting 35 (VPS35), has been reported in Alzheimer’s disease (AD) brains. VPS35 genetic reduc...
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Open AccessA pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles
The vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex system, an ubiquitous multiprotein assembly responsible for sorting and trafficking protein cargos out of the endosomes. VPS...
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Article
Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy
A high circulating level of homocysteine (Hcy), also known as hyperhomocysteinemia, is a risk factor for Alzheimer’s disease (AD). Previous studies show that elevated Hcy promotes brain amyloidosis and behavio...
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Open AccessImpaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease
Impairments in neuronal intracellular calcium (iCa2+) handling may contribute to Alzheimer’s disease (AD) development. Metabolic dysfunction and progressive neuronal loss are associated with AD progression, and m...
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Article
Endosomal sorting and trafficking, the retromer complex and neurodegeneration
The retromer is a highly conserved multimeric protein complex present in all eukaryotic cells whose activity is essential for regulating the recycling and retrieval of numerous protein cargos from the endosome...
