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    Article

    Endothelial dysfunction: mechanisms and contribution to diseases

    The endothelium, lining the inner surface of blood vessels and spanning approximately 3 m2, serves as the largest organ in the body. Comprised of endothelial cells, the endothelium interacts with other bodily com...

    Amir Ajoolabady, Domenico Pratico, Jun Ren in Acta Pharmacologica Sinica (2024)

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    Ferroptosis: A Promising Therapeutic Target for Cardiovascular Diseases

    Cardiovascular diseases (CVDs) refer to a group of conditions that affect the heart and blood vessels and are a leading cause of death worldwide. Ferroptosis is an iron-dependent regulated cell death process t...

    Amir Ajoolabady, Domenico Pratico, Nils Henninger in Ferroptosis in Health and Disease (2023)

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    Article

    Ferroptosis in hepatocellular carcinoma: mechanisms and targeted therapy

    Hepatocellular carcinoma is the most prevalent form of primary liver cancer with a multifactorial aetiology comprising genetic, environmental, and behavioural factors. Evading cell death is a defining hallmark...

    Amir Ajoolabady, Daolin Tang, Guido Kroemer, Jun Ren in British Journal of Cancer (2023)

  4. Article

    Open Access

    ER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments

    Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by gradual loss of memory and cognitive function, which constitutes a heavy burden on the healthcare system globally. Current ...

    Amir Ajoolabady, Dan Lindholm, Jun Ren, Domenico Pratico in Cell Death & Disease (2022)

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    Article

    Multifunctional nanomedicines for targeting epidermal growth factor receptor in colorectal cancer

    Systemic administration of chemotherapeutics by nanocarriers (NCs) functionalized with targeting agents provides a localized accumulation of drugs in the target tissues and cells. Advanced nanoscaled medicamen...

    Mostafa Akbarzadeh Khiavi, Azam Safary, Jaleh Barar in Cellular and Molecular Life Sciences (2020)