-
Article
Endothelial dysfunction: mechanisms and contribution to diseases
The endothelium, lining the inner surface of blood vessels and spanning approximately 3 m2, serves as the largest organ in the body. Comprised of endothelial cells, the endothelium interacts with other bodily com...
-
Chapter
Ferroptosis: A Promising Therapeutic Target for Cardiovascular Diseases
Cardiovascular diseases (CVDs) refer to a group of conditions that affect the heart and blood vessels and are a leading cause of death worldwide. Ferroptosis is an iron-dependent regulated cell death process t...
-
Article
Ferroptosis in hepatocellular carcinoma: mechanisms and targeted therapy
Hepatocellular carcinoma is the most prevalent form of primary liver cancer with a multifactorial aetiology comprising genetic, environmental, and behavioural factors. Evading cell death is a defining hallmark...
-
Article
Open AccessER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by gradual loss of memory and cognitive function, which constitutes a heavy burden on the healthcare system globally. Current ...
-
Article
Multifunctional nanomedicines for targeting epidermal growth factor receptor in colorectal cancer
Systemic administration of chemotherapeutics by nanocarriers (NCs) functionalized with targeting agents provides a localized accumulation of drugs in the target tissues and cells. Advanced nanoscaled medicamen...