-
Article
Open AccessMultivariate analyses of immune markers reveal increases in plasma EN-RAGE in first-episode psychosis patients
Immune cells and cytokines are largely recognized as significant factors in the pathophysiology of neuropsychiatric disorders. The possible role of other blood cells such as leukocytes in events of acute psych...
-
Article
Open AccessDifferential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individuals
Immunity to previously encountered viruses can alter response to unrelated pathogens. We reasoned that similar mechanism may also involve SARS-CoV-2 and thereby affect the specificity and the quality of the im...
-
Article
Open AccessER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by gradual loss of memory and cognitive function, which constitutes a heavy burden on the healthcare system globally. Current ...
-
Article
Open AccessProtective Role of Low Ethanol Administration Following Ischemic Stroke via Recovery of KCC2 and p75NTR Expression
A striking result from epidemiological studies show a correlation between low alcohol intake and lower incidence for ischemic stroke and severity of derived brain injury. Although reduced apoptosis and inflamm...
-
Article
Open AccessCaspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells
Lipid-induced toxicity is part of several human diseases, but the mechanisms involved are not fully understood. Fatty liver is characterized by the expression of different growth and tissue factors. The neurot...
-
Article
Parkinson’s disease: towards better preclinical models and personalized treatments
-
Article
Current disease modifying approaches to treat Parkinson’s disease
Parkinson’s disease (PD is a progressive neurological disorder characterized by the degeneration and death of midbrain dopamine and non-dopamine neurons in the brain leading to motor dysfunctions and other sym...
-
Chapter
PACAP and Neural Progenitor Cells
PACAP is a neuropeptide with a multitude of functions on different cell types and organs including brain tissue. PACAP is relatively highly expressed in embryonic brain indicating a role in neuronal developmen...
-
Article
Open AccessFibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1
Mitochondrial dysfunctions accompany several neurodegenerative disorders and contribute to disease pathogenesis among others in Parkinson’s disease (PD). Peroxisome proliferator-activated receptor γ coactivato...
-
Article
PGC-1α: a master gene that is hard to master
Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a transcriptional coactivator that favorably affects mitochondrial function. This concept is supported by an increasing amount of data in...
-
Article
Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease
Mitochondrial dysfunction and oxidative stress occur in Parkinson’s disease (PD), but little is known about the molecular mechanisms controlling these events. Peroxisome proliferator-activated receptor-gamma c...
-
Article
Downregulation of NF-κB signaling by mutant huntingtin proteins induces oxidative stress and cell death
Accumulation of abnormal proteins and endoplasmic reticulum stress accompany neurodegenerative diseases including Huntington’s disease. We show that the expression of mutant huntingtin proteins with extended p...
-
Article
Regulation of HERG (KCNH2) potassium channel surface expression by diacylglycerol
The HERG (KCNH2) channel is a voltage-sensitive potassium channel mainly expressed in cardiac tissue, but has also been identified in other tissues like neuronal and smooth muscle tissue, and in various tumour...
-
Article
Mylip makes an Idol turn into regulation of LDL receptor
High blood low-density-lipoprotein (LDL) cholesterol is a serious health problem among an increased number of patients in the Western world. Statins and other cholesterol lowering drugs have proven to be benef...
-
Article
Open AccessEvolution of a family of metazoan active-site-serine enzymes from penicillin-binding proteins: a novel facet of the bacterial legacy
Bacterial penicillin-binding proteins and β-lactamases (PBP-βLs) constitute a large family of serine proteases that perform essential functions in the synthesis and maintenance of peptidoglycan. Intriguingly, ...
-
Article
Post-Occlusion Treatment with BDNF Reduces Infarct Size in a Model of Permanent Occlusion of the Middle Cerebral Artery in Rat
In view of the protective effect of brain derived neurotrophic factor (BDNF) against metabolic/excitotoxic insults in vitro, we investigated whether BDNF could limit infarct size after permanent occlusion of the ...
-
Article
Post-occlusion treatment with BDNF reduces infarct size in a model of permanent occlusion of the middle cerebral artery in rat
In view of the protective effect of brain derived neurotrophic factor (BDNF) against metabolic/excitotoxic insultsin vitro, we investigated whether BDNF could limit infarct size after permanent occlusion of the m...
-
Article
Constitutive phosphorylation of TrkC receptors in cultured cerebellar granule neurons might be responsible for the inability of NT-3 to increase neuronal survival and to activate p21 ras
The neurotrophins brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are both expressed in develo** cerebellum in addition to their tyrosine kinase receptors, TrkB and TrkC. In contrast to BD...
-
Article
Role of neurotrophins in preventing glutamate induced neuronal cell death
Neurotrophic factors are important regulators of neuronal survival and differentiation during embryonic development. However, these molecules also act on fully mature neurons and have been shown to rescue cell...
-
Chapter
Nerve Growth Factor (NGF) in the Central Nervous System: Implications for the Treatment of Alzheimer’s Disease
The physiological functions of NGF in the peripheral nervous system are already known for a long time (see Levi-Montalcini and Angeletti, 1968; Greene and Shooter, 1980; Thoenen and Barde, 1980). NGF regulates...
