194 Result(s)
within
Chen**g Zhu
Science, Humanities and Social Sciences, multidisciplinary
Science, multidisciplinary
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Article
Open AccessMinimally invasive technique combined with external fixator in the treatment of pediatric flexion-type humeral supracondylar fractures
Flexion-type pediatric humeral supracondylar fractures are rare, and the reduction technique remains contradictory. A minimally invasive technique using percutaneous leverage reduction combined with an externa...
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Article
Open AccessInfluence of pneumatic transportation on the stability of monoclonal antibodies
Pneumatic transportation systems (PTS) were recently proposed as a method to carry ready-for-injection diluted monoclonal antibodies (mAbs) from the pharmacy to the bedside of patients. This method reduces tra...
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Article
Open AccessStructure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry
Since 2019, SARS-CoV-2 has evolved rapidly and gained resistance to multiple therapeutics targeting the virus. Development of host-directed antivirals offers broad-spectrum intervention against different varia...
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Article
Open AccessBiofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections
The formation of biofilms is closely associated with persistent and chronic infections, and physiological heterogeneity such as pH and oxygen gradients renders biofilms highly resistant to conventional antibio...
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Article
Open AccessBiomimetic single Al-OH site with high acetylcholinesterase-like activity and self-defense ability for neuroprotection
Neurotoxicity of organophosphate compounds (OPs) can catastrophically cause nervous system injury by inhibiting acetylcholinesterase (AChE) expression. Although artificial systems have been developed for indir...
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Article
Open AccessMetallic W/WO2 solid-acid catalyst boosts hydrogen evolution reaction in alkaline electrolyte
The lack of available protons severely lowers the activity of alkaline hydrogen evolution reaction process than that in acids, which can be efficiently accelerated by tuning the coverage and chemical environme...
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Article
Open AccessSnapFISH: a computational pipeline to identify chromatin loops from multiplexed DNA FISH data
Multiplexed DNA fluorescence in situ hybridization (FISH) imaging technologies have been developed to map the folding of chromatin fibers at tens of nanometers and up to several kilobases in resolution in sing...
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Article
Open AccessOrganization of the human intestine at single-cell resolution
The intestine is a complex organ that promotes digestion, extracts nutrients, participates in immune surveillance, maintains critical symbiotic relationships with microbiota and affects overall health1. The intes...
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Open AccessGenome-wide association studies identify OsWRKY53 as a key regulator of salt tolerance in rice
Salinity stress progressively reduces plant growth and productivity, while plant has developed complex signaling pathways to confront salt stress. However, only a few genetic variants have been identified to m...
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Article
Open AccessGold-catalyzed four-component multifunctionalization of alkynes
The alkyne unit is a versatile building block in organic synthesis and the development of selective multifunctionalization of alkynes is an important object of research in this field. Herein, we report an inte...
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Article
Open AccessCatch bond models may explain how force amplifies TCR signaling and antigen discrimination
The TCR integrates forces in its triggering process upon interaction with pMHC. Force elicits TCR catch-slip bonds with strong pMHCs but slip-only bonds with weak pMHCs. We develop two models and apply them to...
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Article
Open AccessIdentification of three cultivated varieties of Scutellaria baicalensis using the complete chloroplast genome as a super-barcode
Scutellaria baicalensis has been one of the most commonly used traditional Chinese medicinal plants in China for more than 2000 years. The three new varieties cultivated could not be distinguished by morphology b...
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Article
Open AccessGrazing-incidence diffraction reveals cellulose and pectin organization in hydrated plant primary cell wall
The primary cell wall is highly hydrated in its native state, yet many structural studies have been conducted on dried samples. Here, we use grazing-incidence wide-angle X-ray scattering (GIWAXS) with a humidi...
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Article
Open AccessAbnormalities in intron retention characterize patients with systemic lupus erythematosus
Regulation of intron retention (IR), a form of alternative splicing, is a newly recognized checkpoint in gene expression. Since there are numerous abnormalities in gene expression in the prototypic autoimmune ...
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Article
Open AccessDevelopment and validation of a risk prediction model for diabetic retinopathy in type 2 diabetic patients
To establish a risk prediction model and make individualized assessment for the susceptible diabetic retinopathy (DR) population in type 2 diabetic mellitus (T2DM) patients. According to the retrieval strategy...
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Article
Open AccessPoly(heptazine imide) ligand exchange enables remarkable low catalyst loadings in heterogeneous metallaphotocatalysis
The development of heterogeneous metallaphotocatalysis is of great interest for sustainable organic synthesis. The rational design and controllable preparation of well-defined (site-isolated) metal/photo bifun...
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Article
Open AccessR-LESS-RP versus C-LESS-RP: a single-institution retrospective comparative study
This study aimed to compare the peri- and postoperative outcomes of patients treated with conventional versus robot-assisted laparoendoscopic single-site radical prostatectomy (C-LESS-RP vs. R-LESS-RP). Data o...
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Article
Open AccessSystematic characterization of chromodomain proteins reveals an H3K9me1/2 reader regulating aging in C. elegans
The chromatin organization modifier domain (chromodomain) is an evolutionally conserved motif across eukaryotic species. The chromodomain mainly functions as a histone methyl-lysine reader to modulate gene exp...
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Article
Open AccessLikely accelerated weakening of Atlantic overturning circulation emerges in optimal salinity fingerprint
The long-term response of the Atlantic meridional overturning circulation (AMOC) to anthropogenic forcing has been difficult to detect from the short direct measurements available due to strong interdecadal va...
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Article
Open AccessModulating stereoselectivity in allylic C(sp3)-H bond arylations via nickel and photoredox catalysis
While significant progress has been made in develo** selective C-H bond cross-couplings in the field of radical chemistry, the site and stereoselectivity remain a long-standing challenge. Here, we present th...
