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Article
Nuclear morphology is shaped by loop-extrusion programs
It is well established that neutrophils adopt malleable polymorphonuclear shapes to migrate through narrow interstitial tissue spaces1–3. However, how polymorphonuclear structures are assembled remains unknown4. ...
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Article
Open AccessSnapFISH: a computational pipeline to identify chromatin loops from multiplexed DNA FISH data
Multiplexed DNA fluorescence in situ hybridization (FISH) imaging technologies have been developed to map the folding of chromatin fibers at tens of nanometers and up to several kilobases in resolution in sing...
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Article
Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis
Nuclear localization of HIPPO-YAP fusion proteins has been implicated in supratentorial ependymoma development. Here, unexpectedly, we find that liquid–liquid phase separation, rather than nuclear localization...
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Article
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens
Antigen receptor loci are organized into variable (V), diversity (D) and joining (J) gene segments that rearrange to generate antigen receptor repertoires. Here, we identified an enhancer (E34) in the murine i...
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Article
Open AccessWHO Functioning and Disability Disaggregation (FDD11) tool: a reliable approach for disaggregating data by disability
There is a global scarcity of good quality disability data, which has contributed to a lack of political will to address the challenges that persons with disabilities face. The current paper proposes a way for...
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Article
Open AccessDemographic and environmental factors associated with disability in India, Laos, and Tajikistan: a population-based cross-sectional study
The number of people experiencing functional limitations due to health conditions (capacity) is expected to increase in low and middle-income countries as populations age and rates of non-communicable disease ...
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Article
Open AccessGenerating comprehensive functioning and disability data worldwide: development process, data analyses strategy and reliability of the WHO and World Bank Model Disability Survey
Data on functioning and disability collected at population level is essential to complement mortality and morbidity, to estimate rehabilitation needs of countries and regions and to monitor the Convention on t...
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Article
Open AccessSnapHiC: a computational pipeline to identify chromatin loops from single-cell Hi-C data
Single-cell Hi-C (scHi-C) analysis has been increasingly used to map chromatin architecture in diverse tissue contexts, but computational tools to define chromatin loops at high resolution from scHi-C data are...
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Article
Open AccessMeasuring functioning and disability using household surveys: metric properties of the brief version of the WHO and World Bank model disability survey
The Model Disability Survey (MDS) is the current standard recommended by WHO to collect functioning and disability data. Answering calls from countries requesting a version to be implemented as a module that c...
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Article
Open AccessIdentifying key environmental barriers experienced by persons with mild, moderate, or severe disability in Bankim Health District, Cameroon: a policy-targeted secondary analysis of data obtained with the World Bank and WHO model disability survey
Comprehensive data is key for evidence-informed policy aiming to improve the lives of persons experiencing different levels of disability. The objective of this paper was to identify the environmental barriers...
