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Article
Open AccessCatch bond models may explain how force amplifies TCR signaling and antigen discrimination
The TCR integrates forces in its triggering process upon interaction with pMHC. Force elicits TCR catch-slip bonds with strong pMHCs but slip-only bonds with weak pMHCs. We develop two models and apply them to...
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Article
Nonlinear Time-Domain Theory for the Simulation of Moored Floating Body Motion
Nonlinear wave loads can induce low-frequency and high-frequency resonance motions of a moored platform in deep water. For the analysis of the nonlinear response of an offshore platform under the action of irr...
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Article
Open AccessThe mechanical response of talin
Talin, a force-bearing cytoplasmic adapter essential for integrin-mediated cell adhesion, links the actin cytoskeleton to integrin-based cell–extracellular matrix adhesions at the plasma membrane. Its C-termin...
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Article
Recent progress on the mechanics of sharply bent DNA
Despite extensive studies on the mechanics of DNA under external constrains, such as tension, torsion, and bending, several important aspects have remained poorly understood. One biologically important example...
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Article
Correction: Corrigendum: Force-dependent conformational switch of α-catenin controls vinculin binding
Nature Communications 5: Article number: 4525 (2014); Published: 31 July 2014; Updated: 4 March 2015 The affiliation details for Jie Yan are incorrect in this Article. The correct affiliation details for this ...
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Article
Force-dependent conformational switch of α-catenin controls vinculin binding
Force sensing at cadherin-mediated adhesions is critical for their proper function. α-Catenin, which links cadherins to actomyosin, has a crucial role in this mechanosensing process. It has been hypothesized t...
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Article
Open AccessMechanical activation of vinculin binding to talin locks talin in an unfolded conformation
The force-dependent interaction between talin and vinculin plays a crucial role in the initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the mechano-sensitive compact N-te...
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Article
Effect of pontoons on free surface elevation around a TLP platform
Tension leg platform (TLP) is a typical compliant offshore structure for oil/gas resources exploitation. In the design process, the prediction of the free surface elevation is of great importance for the deter...
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Article
Open AccessMechanosensing of DNA bending in a single specific protein-DNA complex
Many crucial biological processes are regulated by mechanical stimuli. Here, we report new findings that pico-Newton forces can drastically affect the stability of the site-specific DNA binding of a single tra...
