-
Article
Publisher Correction: The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8+T cell fates
-
Article
The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8+ T cell fates
Antigen-experienced CD8+ T cells form effector and central memory T cells (TEM and TCM cells, respectively); however, the mechanism(s) controlling their lineage plasticity remains incompletely understood. Here we...
-
Article
MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner
H3K4me1 methyltransferases MLL3 (KMT2C) and MLL4 (KMT2D) are critical for enhancer activation, cell differentiation and development. However, roles of MLL3/4 enzymatic activities and MLL3/4-mediated enhancer H...
-
Article
Open AccessAbnormalities in intron retention characterize patients with systemic lupus erythematosus
Regulation of intron retention (IR), a form of alternative splicing, is a newly recognized checkpoint in gene expression. Since there are numerous abnormalities in gene expression in the prototypic autoimmune ...
-
Article
Tcf1–CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis
CD8+ T cell homeostasis is maintained by the cytokines IL-7 and IL-15. Here we show that transcription factors Tcf1 and Lef1 were intrinsically required for homeostatic proliferation of CD8+ T cells. Multiomics a...
-
Article
Publisher Correction: Tcf1 preprograms the mobilization of glycolysis in central memory CD8+ T cells during recall responses
-
Article
Tcf1 preprograms the mobilization of glycolysis in central memory CD8+ T cells during recall responses
The mechanisms underlying the heightened protection mediated by central memory CD8+ T (TCM) cells remain unclear. Here we show that the transcription factor Tcf1 was required in resting TCM cells to generate seco...
-
Article
Open AccessTcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture
T cell identity is established during thymic development, but how it is maintained in the periphery remains unknown. Here we show that ablating Tcf1 and Lef1 transcription factors in mature CD8+ T cells aberrantl...
-
Article
Open AccessInterplay of BAF and MLL4 promotes cell type-specific enhancer activation
Cell type-specific enhancers are activated by coordinated actions of lineage-determining transcription factors (LDTFs) and chromatin regulators. The SWI/SNF chromatin remodeling complex BAF and the histone H3K...
-
Article
RECOGNICER: A coarse-graining approach for identifying broad domains from ChIP-seq data
Histone modifications are major factors that define chromatin states and have functions in regulating gene expression in eukaryotic cells. Chromatin immunoprecipitation coupled with high-throughput sequencing ...
-
Article
miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer
Platinum drugs are used in first-line to treat ovarian cancer, but most of the patients eventually generate resistance after treatment with these drugs. Although both c-Myc and EZH2 have been implicated in reg...
-
Article
Open AccessEzh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf
Ezh2 is an histone methyltransferase (HMT) that catalyzes H3K27me3 and functions in TH1, TH2, and Treg cells primarily via HMT activity. Here we show that Ezh2 ablation impairs T follicular helper (TFH) cell diff...
-
Article
Open AccessPredicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features
The CCCTC-binding zinc-finger protein (CTCF)-mediated network of long-range chromatin interactions is important for genome organization and function. Although this network has been considered largely invariant...
-
Article
Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance
Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug resistance. Emerging observations suggest a role of reactive oxyge...
-
Article
Open AccessBrd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis
The epigenomic reader Brd4 is an important drug target for cancers. However, its role in cell differentiation and animal development remains largely unclear. Using two conditional knockout mouse strains and de...
-
Article
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage
Xue and colleagues show that Runx3−/− CD8+ T effector cells aberrantly upregulate genes characteristic of TFH cell lineage and exhibit impaired induction of cytotoxic molecules.
-
Article
Open AccessRapid Recall Ability of Memory T cells is Encoded in their Epigenome
Even though T-cell receptor (TCR) stimulation together with co-stimulation is sufficient for the activation of both naïve and memory T cells, the memory cells are capable of producing lineage specific cytokine...
-
Article
Open AccessLineage relationship of CD8+ T cell subsets is revealed by progressive changes in the epigenetic landscape
To better elucidate epigenetic mechanisms that correlate with the dynamic gene expression program observed upon T-cell differentiation, we investigated the genomic landscape of histone modifications in naive a...
-
Article
Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity
Xue and colleagues show that the transcription factors Tcf1 and Lef1 suppress CD4+ T lineage genes in CD8+ T cells through intrinsic histone deacetylase (HDAC) activity.
-
Article
LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6
Follicular helper T cells (TFH cells) are specialized effector CD4+ T cells that help B cells develop germinal centers and memory. Crotty and colleagues show that the transcription factors LEF-1 and TCF-1 are req...
